Characteristics Associated With Physical Function Trajectories in Older Adults With Cancer During Chemotherapy

Journal of Pain and Symptom Management
Melisa L WongC Miaskowski

Abstract

Studies on physical function trajectories in older adults during chemotherapy remain limited. The objective of this study was to determine demographic, clinical, and symptom characteristics associated with initial levels as well as trajectories of physical function over two cycles of chemotherapy in adults aged ≥65 years with breast, gastrointestinal, gynecological, or lung cancer. Older adults with cancer (n = 363) who had received chemotherapy within the preceding four weeks were assessed six times over two cycles of chemotherapy using the Short Form-12 Physical Component Summary (PCS) score. Hierarchical linear modeling was used to evaluate for interindividual variability in initial levels and trajectories of PCS scores. Mean age was 71.4 years (SD 5.5). Mean PCS score at enrollment was 40.5 (SD .45). On average, PCS scores decreased slightly (i.e., 0.21 points) at each subsequent assessment. Lower PCS scores at enrollment were associated with older age, greater comorbidity, being unemployed, lack of regular exercise, higher morning fatigue, lower evening energy, occurrence of pain, lower trait anxiety, and lower attentional function. Only higher morning fatigue and lower enrollment PCS scores were associated with decrements...Continue Reading

Citations

Mar 9, 2019·Journal of the American Geriatrics Society·Chintan PandyaSupriya G Mohile
May 22, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kyuwan LeeChristina M Dieli-Conwright
Apr 16, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Kah Poh LohMelisa L Wong

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