Characteristics, Biological Properties and Analytical Methods of Piperine: A Review

Critical Reviews in Analytical Chemistry
Christian Rafael Quijia, Marlus Chorilli

Abstract

Piperine (PIP) is a natural alkaloid isolated from Piper longum L. that presents antioxidant, anticonvulsant, antimicrobial, neuroprotective, larvicidal, antiparasitic, anticancer effect and other pharmacological properties. However, the low aqueous solubility is the main barrier to its development from the laboratory to the clinic as a drug. Several strategies have been used to overcome this obstacle, like the incorporation of PIP into different drug delivery systems turned out to be highly efficient. In addition, several methods for the quantitative and qualitative analysis of PIP in various raw materials, including biological fluids (plasma, urine, metabolites, brain), plants and drug delivery systems, were investigated. Most recently high-performance liquid chromatography was used together with several detectors for this purpose. Therefore, this review presents a summary of characteristics chemical and biological properties of PIP as well as several techniques and analytical methods to optimize the analytical signal, increase sensitivity, selectivity and reduce the effects of interference for this drug.

References

Mar 21, 2002·Journal of Agricultural and Food Chemistry·Il-Kwon ParkYoung-Joon Ahn
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Young-Cheol YangHoi-Seon Lee
Jul 26, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sunil BajadK L Bedi
Sep 11, 2002·Analytical and Bioanalytical Chemistry·Waldemar Ternes, Edburga L Krause
Jan 30, 2003·Clinical & Experimental Metastasis·C R Pradeep, G Kuttan
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manthena V S VarmaRamesh Panchagnula
Aug 9, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sunil BajadKasturi L Bedi
Oct 1, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Panda, A Kar
Mar 12, 2004·Journal of Ethnopharmacology·E S Sunila, G Kuttan
Mar 24, 2004·Toxicology·Ram K S DograRavi Shanker
Jun 5, 2004·Bioorganic & Medicinal Chemistry Letters·Tatiana Santana RibeiroMarco Edilson Freire de Lima
Jul 3, 2004·Redox Report : Communications in Free Radical Research·R S VijayakumarN Nalini
Jul 1, 2005·Organic Letters·Kun WeiTamotsu Nikaido
Jan 27, 2006·Antimicrobial Agents and Chemotherapy·Inshad Ali KhanGhulam Nabi Qazi
Jun 2, 2007·Journal of Applied Toxicology : JAT·Daniel P BezerraLetícia V Costa-Lotufo
Aug 11, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B-S ParkS-E Lee
Aug 19, 2007·Journal of Asian Natural Products Research·Song LiMin-Wei Wang
Apr 5, 2008·Journal of Agricultural and Food Chemistry·Mendel FriedmanNobuyuki Kozukue
Apr 12, 2008·Journal of Natural Medicines·Niranjan KanakiMandapati Rajani
Jun 9, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R H Raghavendra, K Akhilender Naidu
Nov 10, 2009·Breast Cancer Research and Treatment·Madhuri KakaralaMax S Wicha
Dec 26, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pennapa ChonpathompikunlertSupaporn Muchimapura
May 15, 2010·Journal of Agricultural and Food Chemistry·Madhuri KakaralaDean E Brenner
Sep 11, 2010·Journal of Medicinal Food·Malik Hassan Mehmood, Anwarul Hassan Gilani
Apr 12, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qing-Qiu MaoChun-Tao Che
Jun 18, 2011·Journal of Medical Microbiology·Zahid Mehmood MirzaInshad Ali Khan
Jun 30, 2011·Molecular Nutrition & Food Research·Jeremy J JohnsonNihal Ahmad
Aug 23, 2011·Natural Product Research·Vidadala Rama Subba RaoJanaswamy Madhusudana Rao
Sep 8, 2011·International Journal of Ayurveda Research·Balendu Prakash
Dec 30, 2011·Cellular and Molecular Neurobiology·Qing-Qiu MaoChun-Tao Che
Jul 24, 2012·The Journal of Nutritional Biochemistry·Pallavi ShrivastavaFakhrul Islam
Apr 23, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Haolong LiuXia Wu

❮ Previous
Next ❯

Citations

Oct 1, 2019·Expert Opinion on Drug Metabolism & Toxicology·Tianjing Ren, Zhong Zuo
Jan 21, 2020·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Toshiyuki MizumotoNaoki Sugimoto
Feb 4, 2021·Journal of Natural Products·Sharna-Kay Daley, Geoffrey A Cordell
Dec 11, 2020·Experimental Parasitology·Kourosh CheraghipourAbdolrazagh Marzban

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

Soluplus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.