Mar 1, 1977

Characteristics of 24S and 35S virus-specific RNA in cells infected with Newcastle disease virus

Voprosy virusologii
I S LukashevichN V Kaverin

Abstract

The properties of 24S and 35S virus-specific RNAs of Newcastle disease virus were studied after denaturation. It was shown that 60-80% of 24S and 35SRNA consisted of agglomerates of molecules of virus-specific 18S RNA. Undissociable upon denaturation, 24S RNA contained mainly the same components as undenaturated RNA and consisted completely of sequences of virus-specifis 18S RNA. Undissociable 35S RNA contained no "heavy" heterogenous material present in the intact undenaturated RNA and 75% of it consisted os sequences of 18S virus-specific RNA. Some sequences present in undissociable 24S RNA were absent in undissociable 35S RNA. The aggregation of virus-specific na-transcripts and subsequent formation of covalent bonds between transcripts as well as possible formation of "solid" transcripts of the adjacent genes are discussed.

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Mentioned in this Paper

Newcastle disease virus
Covalent Interaction
RNA Denaturation
Aggregation
Newcastle Disease
Denaturation
Genomic Hybridization
RNA, Viral
RNA
RNA, Ribosomal, 18S

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