Characteristics of Acute Gout Flare in Patients Initiated on Intravenous Bumetanide for Acute Heart Failure Exacerbation

Curēus
Stephanie Jeong, Irene J Tan

Abstract

Background Heart failure is a clinical syndrome with significant morbidity, mortality, and financial burden. These factors are magnified in patients with associated comorbidities. Therefore, addressing such conditions is critical in decreasing healthcare costs and improving patient outcomes. Gout is a major comorbidity in patients with heart failure. Acute gout flares that occur in the context of acute heart failure exacerbations (AHFE) form an independent risk factor for increased readmissions or death. In this study, we characterized the frequency and outcomes of acute gout flares in patients treated with intravenous (IV) bumetanide for AHFE. Methods This single-center retrospective cohort study included 130 adult patients admitted in a tertiary-care hospital between August 2016 and June 2018. Chart review identified patients who were hospitalized for AHFE with International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code I50, received IV bumetanide, and developed an acute gout flare. Data were analyzed using the chi-square test for categorical variables and the two-sample t-test for continuous variables. Results The annualized frequency of acute gout while receiving IV bumetanide for AHFE was 7.17%. Chroni...Continue Reading

References

Mar 27, 2003·Journal of the American Geriatrics Society·James X ZhangMarshall H Chin
May 16, 2003·The New England Journal of Medicine·Mariell Jessup, Susan Brozena
Oct 3, 2003·Journal of the American College of Cardiology·Joel B BraunsteinAlbert W Wu
Aug 11, 2010·Archives of Internal Medicine·George ThanassoulisLouise Pilote
Apr 26, 2013·Circulation. Heart Failure·Paul A HeidenreichUNKNOWN Stroke Council
Aug 31, 2013·Circulation Research·Véronique L Roger

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