PMID: 11899816Mar 20, 2002Paper

Characteristics of aggressive and protective factors in erosive lesions of gastroduodenal mucosa

Terapevticheskiĭ arkhiv
E V Belova, Ia M Vakhrushev

Abstract

To investigate aggressive-protective factors in patients with erosive lesions of gastroduodenal mucosa. Intragastric pH-metry, tests for Helicobacter pylori, lysozyme activity, content of bile acid in gastric juice, components of gastric mucous gel were made in 106 patients. It is shown that there are two alternative paths of erosions development in the gastroduodenal zone: infectious and non-infectious. In patients infected with Helicobacter pylori, lowering of a protective ability of the mucous gel is caused by prevalence of synthesis of immature mucous components while in non-infected patients this happens as a result of high catabolism of mucous components.

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