PMID: 25791658Mar 21, 2015Paper

Characteristics of airway hyperresponsiveness in children with chronic cough of different causes

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Xingmei YuKefang Lai

Abstract

To study the characteristics of airway hyperresponsiveness in children with different causes of chronic cough. A prospective study was conducted in children suffering from chronic cough caused by a single reason at the department of respirology of Children's Hospital of Soochow University from April 2012 to December 2013. Bronchial provocation test, induced sputum eosinophil count, and exhale nitric oxide were detected at beginning and 4 weeks later. The severity of the CVA was classified according to the integral dose of histamine which resulted in a 20% (PD20) fall in forced expiratory volume in 1 s (FEV1). All patients received treatment according to the recommended guidelines for chronic cough in children of China. According to the responses to the treatment and the results of physical examinations and laboratory findings, a final diagnosis was confirmed. A total of 66 children were enrolled in this study, including cough variant asthma (CVA)in 17, upper airway cough syndrome (UACS) in 37, and post infection cough (PIC) in 12 cases. Positive AHR in CVA, UACS, and PIC groups was found in 17, 13, and 9 cases respectively at the first visit, and after 4 weeks, it was found in 17, 5, and 2 cases respectively. The severity of AH...Continue Reading

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.