PMID: 6972784Apr 14, 1981Paper

Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts

Biochimica Et Biophysica Acta
P E Daddona, W N Kelley

Abstract

An inherited deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is associated with an autosomal recessive form of severe combined immunodeficiency disease. Affected patients exhibit markedly reduced or absent adenosine deaminating activity in various tissues. In this study we have demonstrated the presence of a low level aminohydrolase activity in 11 different normal and adenosine deaminase-deficient lymphoblast cell lines which is apparently distinct from normal adenosine deaminase. Based on enzymatic, physical and immunoreactive properties, this lymphoblast aminohydrolase does not appear to be related to adenosine deaminase and is most likely coded for by a different gene locus. In future investigations designed to characterize mutant forms of adenosine deaminase, it will be important to distinguish this lymphoblast aminohydrolase activity from putative products of the adenosine deaminase gene locus.

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W P SchraderH J Meuwissen
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A CohenD W Martin
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B S MitchellW N Kelley
Sep 1, 1979·The Journal of Clinical Investigation·P E DaddonaW N Kelley
Oct 1, 1979·The Journal of Clinical Investigation·R HirschhornW Borkowsky
Oct 24, 1979·Biochimica Et Biophysica Acta·P E Daddona, W N Kelley
Sep 15, 1977·Nature·D M SwallowD A Hopkinson
Apr 8, 1974·Biochemical and Biophysical Research Communications·M B Van der WeydenW N Kelley
Oct 1, 1971·Annals of Human Genetics·Y H EdwardsH Harris

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Citations

Sep 15, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·J L PérignonM Derycke
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P W KantoffJ J Hutton
Aug 1, 1983·The Journal of Clinical Investigation·P E DaddonaC A Koller
Jun 1, 1991·Biochemical Pharmacology·J G Niedzwicki, D R Abernethy
Feb 24, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·R GuieuB Dussol
Jul 1, 1991·American Journal of Hematology·J G NiedzwickiD R Abernethy
Jun 2, 2005·The Biochemical Journal·Andrey V Zavialov, Ake Engström
Jul 12, 2020·Pediatric Rheumatology Online Journal·Sarah M BowersKelly L Brown

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