Characteristics of anginal patients with high resting myocardial blood flow measured with N-13 ammonia PET/CT

Nuclear Medicine Communications
Sang-Geon ChoHee-Seung Bom

Abstract

We hypothesized that anginal patients with low coronary flow reserve (CFR) could have variable clinical features according to resting myocardial blood flow (MBF). Therefore, we analyzed the clinical and imaging characteristics according to resting MBF in anginal patients. We enrolled 70 patients who underwent N-13 ammonia PET-computed tomography (CT) for evaluation of angina. Resting and stress MBF values were obtained and resting MBF was corrected with rate-pressure product to exclude the effect of heart rate and blood pressure on resting MBF. Clinical and imaging characteristics were compared on the basis of MBF and CFR. Among patients with CFR less than 2.0, those with high resting MBF (≥1.0 ml/min/g) had significantly fewer number of smokers, were younger, had lower Agatston calcium scores, and had less coronary stenosis compared with those with low resting MBF (<1.0 ml/min/g). In contrast, there was no significant difference in clinical or imaging findings according to resting MBF when compared among all patients or within those with CFR greater than or equal to 2.0. The subgroup analysis of patients with CFR less than 2.0 revealed lower Agatston calcium score and less coronary stenosis in patients with high resting MBF re...Continue Reading

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Citations

Sep 30, 2018·The International Journal of Cardiovascular Imaging·Andrea G Monroy-GonzalezRene A Tio
Apr 8, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Chetsadaporn PromteangtrongChanisa Chotipanich

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