Characteristics of antibody responses induced in mice by protein allergens

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J HiltonI Kimber

Abstract

Whereas many foreign proteins are immunogenic, only a proportion is also allergenic, having the capacity to induce the quality of immune response necessary to support the production of IgE antibody. We have demonstrated previously that intraperitoneal administration to mice of proteins such as ovalbumin (OVA) or the industrial enzyme A. oryzae lipase, which possess significant allergenic potential, stimulates the production of both IgG and IgE antibody. Identical exposure to bovine serum albumin (BSA), a protein with limited potential to cause immediate respiratory or gastrointestinal hypersensitivity reactions, induced IgG responses only. In the current investigations, the quality of immune responses induced following exposure to these proteins via mucosal tissue (intranasal) has been compared with those provoked following administration via a non-mucosal (intraperitoneal) route of exposure. Intranasal or intraperitoneal administration of BSA, OVA or A. oryzae lipase elicited in each case vigorous IgG and IgG1 antibody responses. For all three proteins, at every concentration tested, and via both routes of exposure, IgG1 antibody titres paralleled closely IgG titres. However, the three materials displayed a differential potent...Continue Reading

References

Jan 1, 1977·The Journal of the Society of Occupational Medicine·C P JuniperA K Kinshott
Jan 1, 1975·International Archives of Allergy and Applied Immunology·Z OvaryS Kojima
Jan 1, 1988·The Journal of Experimental Medicine·C M SnapperW E Paul
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F D FinkelmanW E Paul
Jan 1, 1987·American Journal of Industrial Medicine·A B SmithG A Carson
Dec 1, 1987·The Journal of Allergy and Clinical Immunology·D I BernsteinG Carson
Jul 1, 1985·Clinical Reviews in Allergy·D D Metcalfe
Feb 1, 1971·The Journal of Allergy·R S Shapiro, B C Eisenberg
Nov 1, 1984·The Journal of the Society of Occupational Medicine·C P Juniper, D M Roberts
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·H L RitzK Sarlo
Jun 1, 1995·Journal of the American College of Nutrition·A FiocchiC L Galli
Feb 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T T KawabataP A Horn
Nov 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M K RobinsonT T Kawabata

❮ Previous
Next ❯

Citations

Apr 17, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Oct 3, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L Blaikie, D A Basketter
Mar 21, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Apr 27, 2001·Toxicology Letters·I Kimber, R J Dearman
Apr 27, 2001·Toxicology Letters·A H Penninks, L M Knippels
Apr 27, 2001·Toxicology Letters·R J Dearman, I Kimber
Apr 5, 2003·Toxicology Letters·Ian KimberRebecca J Dearman
Nov 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christal C Bowman, Maryjane K Selgrade
Feb 8, 2003·Environmental Health Perspectives·Ian KimberRebecca J Dearman
Feb 8, 2003·Environmental Health Perspectives·Léon M J Knippels, André H Penninks
Jun 27, 2003·Environmental Health Perspectives·Ian KimberRicki M Helm
Apr 15, 2003·The Proceedings of the Nutrition Society·Ian Kimber, Rebecca J Dearman
Oct 30, 2008·Regulatory Toxicology and Pharmacology : RTP·Christal C Bowman, MaryJane K Selgrade
Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Shih-Chang HsuShau-Ku Huang
Jun 12, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M KriegerJ A Hotchkiss
Apr 1, 2021·Molecular Pharmaceutics·Alessandra SpadaAfsaneh Lavasanifar
Apr 20, 2001·Journal of Agricultural and Food Chemistry·K AritaA Kato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
R J DearmanI Kimber
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L M KnippelsG F Houben
© 2021 Meta ULC. All rights reserved