PMID: 9553754Apr 29, 1998Paper

Characteristics of biochemical markers in patients with metabolic bone disorders

Endocrine Research
H HoshinoT Inoue

Abstract

Biochemical markers of bone turnover are expected to have some different characteristics among bone metabolic disorders. We compared bone formation markers: serum total alkaline phosphatase (s-Alp), serum osteocalcin (s-OC) and serum carboxy-terminal propeptide of type I collagen (s-PICP); and bone resorption markers: serum carboxy-terminal telopeptide of type I collagen (s-ICTP), urinary pyridinoline (u-Pyr) and urinary deoxypyridinoline (u-Dpyr) to examine which marker is the most suitable and reliable to evaluate bone turnover in patients with osteoporosis (n = 29), osteomalacia (n = 10), primary hyperparathyroidism (n = 6) and renal osteodystrophy (n = 21). The value of s-Alp in the osteomalacia group was significantly higher than those in the normal control group and the osteoporosis group (p < 0.001), and T-score of s-Alp was significantly higher than those of s-OC and s-PICP in the osteomalacia group. The values of u-Pyr and u-Dpyr in the primary hyperparathyroidism group were significantly higher than those in the other groups (p < 0.001). S-PICP, which are not dependent upon renal function, was much higher in the renal osteodystrophy group than in all other groups. In the osteoporosis group, T-score of s-ICTP was signi...Continue Reading

References

Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P R EbelingB L Riggs
Nov 1, 1983·The Journal of Clinical Endocrinology and Metabolism·P D DelmasB L Riggs

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Citations

Jan 9, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A F SchillingM Amling
Nov 26, 2003·Mayo Clinic Women's Healthsource
Apr 28, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·C ChappardM Paillard
May 26, 2004·Clinics in Laboratory Medicine·Catherine A Hammett-Stabler

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