Characteristics of cellular immune responses to collagen type I or collagen type II

Cellular Immunology
L ButlerK Phadke

Abstract

We have examined the murine cell-mediated immune (CMI) response to collagens type I (CI) and type II (CII) as measured by in vivo delayed-type hypersensitivity responses. We have verified the histopathology and kinetics of the cell-mediated immune responses. Predominant cell-mediated responses were obtained 7, 10, or 14 days following immunization. A presumed antibody-mediated reaction was observed at later times (e.g., greater than 21 days following immunization). The CMI responses to the collagens show a strain-dependent relationship. For CI, the CMI response profile shows H-2b greater than or equal to H-2k = H-2q much greater than H-2d. For bovine CII, the response profile is H-2d greater than H-2b = H-2k = H-2q; the chick CII response profile is H-2q = H-2k greater than H-2b = H-2d, and in limited testing, only the H-2q strain could generate murine CII-specific cell-mediated immune responses. The CII-specific CMI response is cross-reactive with CII from several species of animals, but not with CI. Further, the collagen-specific CMI response can be elicited with certain cyanogen-bromide fragments of bovine CII. Finally, our study also demonstrates that there is a non-H-2-linked locus(i) involved in the development of CII-ind...Continue Reading

References

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Citations

Jul 1, 1992·Scandinavian Journal of Immunology·J S EllisD R Katz
Mar 1, 1988·The Journal of Experimental Medicine·S BanerjeeC S David
Aug 5, 2009·Journal of Biomedical Materials Research. Part a·Matthew J SmithKimber L White
Jun 1, 1993·Annals of Medicine·R HolmdahlE Vuorio
Sep 1, 1988·International Reviews of Immunology·R HolmdahlL Klareskog
Jul 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R HolmdahlJ Mo

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