PMID: 6410499Aug 1, 1983Paper

Characteristics of chicken intraembryonic cells that express B-L (Ia-like) antigen under the influence of cultured bursal epithelium

Scandinavian Journal of Immunology
E EerolaA Toivanen

Abstract

In-vitro-cultured bursal epithelium (BE) and BE-conditioned medium (BECM) induce B-L antigen on chicken intraembryonic cells. Cells prepared from 9-day-old intraembryonic mesoderm were fractionated in accordance with cell size by linear albumin gradient sedimentation at 1 g. Two cell types could be distinguished on which expression of the B-L antigen was altered after a 6-h incubation with the bursal epithelial component. One fraction contained small mononuclear cells with low sedimentation velocity (less than or equal to 3 mm/h) and low spontaneous proliferation activity. These cells responded strongly to BECM and showed a slight but not significant response to BE (index after incubation with BECM 3.8, with BE 1.7, as compared with RPMI medium control). The other fraction was composed of large mononuclear cells with sedimentation velocity greater than 9 mm/h and with high spontaneous proliferation. These cells showed a response of equal magnitude to both BE and BECM (index after incubation with BE 2.0, with BECM 2.3). These results suggest that the bursa of Fabricius has influence on two different cell types: a large, probably primitive undifferentiated cell, responding equally to bursal cellular contacts and BE culture supern...Continue Reading

References

Jul 23, 1976·Science·A BrandG Goldstein
Jan 1, 1977·Journal of Immunological Methods·J Galton, J Ivanyi
Jun 1, 1969·Journal of Cellular Physiology·R G Miller, R A Phillips
Jan 1, 1980·Scandinavian Journal of Immunology·O LassilaF Dieterlen-Lièvre
Jan 1, 1981·Journal of Immunological Methods·J S NowakD G Gilmour
Jan 1, 1981·Advances in Immunology·P W Kincade
Jan 1, 1982·Immunogenetics·W E BrilesG Wick
Jul 15, 1980·Cellular Immunology·E Eerola

❮ Previous
Next ❯

Citations

Nov 14, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Francisco J Muñoz, Mónica De la Fuente

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.