Characteristics of Circulatory γδ T cells in Patients with Symptomatic Chronic Hepatitis B Infection.

Viral Immunology
Dimpu GogoiVainav Patel

Abstract

Hepatitis B is a viral infection that can cause serious liver disease. Chronic hepatitis B (CHB) infection places individuals at higher risk of developing cirrhosis of the liver and hepatocellular cancer. Immune dysfunction, including altered distribution and functional status of T cell immunity, is a contributor to hepatitis B virus (HBV) pathogenesis. In this study, we examined the distribution of circulating γδ T cell subpopulations and levels of cell surface expression of suppressive markers on γδ T cells in individuals with CHB infection and clinical liver disease. A significantly higher proportion of terminally differentiated (TEMRA) (CD27-CD45RA+) γδ T cells along with significantly lower percentages of central memory (CD27+CD45RA-) and effector memory (CD27-CD45RA-) γδ T cells were observed in peripheral blood of these individuals. The expression of exhaustion markers-Tim-3 and Lag-3 was elevated in γδ T cells from CHB-infected individuals compared with healthy controls (HC) and blockade of these exhaustion markers resulted in restoration of interferon gamma (IFN-γ) secretion by γδ T cells. In addition, γδ T cells from CHB patients expressed increased levels of CD69, another important regulator of immune responses. Toge...Continue Reading

References

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Methods Mentioned

BETA
density gradient centrifugation
fluorescence activated cell sorting
enzyme-linked immunosorbent assay
FACS
PMA
flow cytometry

Software Mentioned

GraphPad Prism
Tree Star
TreeStar
CXP
FlowJo

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