PMID: 2491606Jan 1, 1989Paper

Characteristics of clometacin-induced hepatitis with special reference to the presence of anti-actin cable antibodies

Autoimmunity
S IslamJ C Homberg

Abstract

The clinical, biochemical, histopathological and immunological features of 30 cases of clometacin-induced hepatitis are described. The age range of the patients was 32-84 years with a notable female predominance of 29:1. The hepatitis was highly cytolytic with high values of transaminases but with little or no cholestasis. Gammaglobulins were higher than 18 g/l in 73% of the cases. 25 liver biopsies were performed and showed acute hepatitis with a predominant centrilobular necrosis in 17; chronic aggressive hepatitis was noted in 8 cases but 1 showed concomitant cirrhotic changes. Anti-tissue antibodies were looked for in all cases. Anti-smooth muscle antibodies of anti-actin cable type (titre 1/80 to 1/2, 560) were detected in 19 cases, anti-nucleus antibodies in 16 cases which were associated to the former in 14 cases. The above findings show that clometacin produces a hepatitis syndrome quite akin to autoimmune chronic active hepatitis (lupoid hepatitis) and to the hepatopathy induced by oxyphenisatin.

References

Mar 1, 1977·Clinical Pharmacology and Therapeutics·F E Karch, L Lasagna
Jun 1, 1976·The American Journal of Medicine·J S RodmanS I Gutman
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C HombergM Beaugrand
Oct 7, 1971·The New England Journal of Medicine·T B ReynoldsS Yamada
Apr 1, 1973·Australian and New Zealand Journal of Medicine·W G CooksleyL W Powell
Jan 1, 1972·Scandinavian Journal of Gastroenterology·E GjoneG Husby
Dec 11, 1969·The New England Journal of Medicine·V Ronnov-Jessen, A Tjernlund
Jan 1, 1980·Annals of Internal Medicine·J R SharpH J Zimmerman
Jan 1, 1980·Annals of Internal Medicine·M BlackN Schatz

❮ Previous
Next ❯

Citations

Jan 1, 1995·Critical Reviews in Toxicology·U A BoelsterliA Kretz-Rommel
May 1, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ufuk Bariş KuzuErtuğrul Kayaçetin
Mar 23, 2017·Biochemistry. Biokhimii︠a︡·N P SudakovYu M Konstantinov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Related Papers

The Netherlands Journal of Medicine
E L de BruyneA Dees
AIHA Journal : a Journal for the Science of Occupational and Environmental Health and Safety
Raymond BoucherManny Vazquez
© 2022 Meta ULC. All rights reserved