Characteristics of diaphragm muscle fibre types in hibernating squirrels

Respiration Physiology
W D ReidWilliam K Milsom

Abstract

Muscle samples from the diaphragms of 7 full-awake (FA), 10 winter-awake (WA), and 8 hibernating (H) squirrels (Spermophilus lateralis) were quick frozen, sectioned and processed for NADH-TR reaction end-product and myofibrillar-ATPase. Both WA and H squirrels showed small increases in diaphragm weight, reductions in body weight, and hence, significant increases in the diaphragm weight to body weight ratio compared to FA squirrels. They also showed increases in muscle fibre type cross-sectional areas and in the oxidative capacity of type 2b fibres as well as a reduction in capillary density. Furthermore, there also was an increase in the proportion of type 2b fibres in the diaphragm of the H squirrels. Thus, despite the dramatically reduced ventilation associated with hibernation, H squirrels exhibited (1) hypertrophy of the diaphragm which may represent an adaptive response that enables them to work against a stiffer chest wall, and (2) an increased oxidative capacity which enables them to fuel this with fat.

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Citations

Jun 8, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bryan C RourkeVincent J Caiozzo
Aug 13, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Megan M NowellBryan C Rourke
Sep 1, 1995·Respiration Physiology·W K Milsom, W D Reid
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hyung ChoiBryan C Rourke
Jul 3, 2013·Integrative and Comparative Biology·Brad E ErismanRobert R Warner
Apr 20, 2016·The Journal of Experimental Biology·Joseph M Santin, Lynn K Hartzler
Jan 23, 2016·The Journal of Experimental Biology·Clark J Cotton
Jan 18, 2017·The Journal of Experimental Biology·Joseph M Santin, Lynn K Hartzler
Dec 3, 2014·The Journal of Experimental Biology·Allyson G HindleSandra L Martin

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