PMID: 6397676Dec 1, 1984Paper

Characteristics of drug absorption via the rectal route

Methods and Findings in Experimental and Clinical Pharmacology
S Muranishi

Abstract

The characteristics of drug absorption from the colorectal area are summarized as follows: colorectal absorption is a simple diffusion process through the lipoidal membrane in which carrier-mediated mechanisms play no role; most of the rates of absorption increase with increasing solubility and release of drugs by vehicles or adjuvants, although drug-adjuvant interaction is related to the decreased absorption rate; membrane-active adjuvants promoting absorption are more effective in the colorectal area than in the upper gastrointestinal tract; the promotive effect on absorption by fatty acids or their monoglycerides in micellar state is stronger in unsaturated long-chain compounds than in saturated ones, and their action is transient; their promotive absorption is applicable not only to small molecules but also large molecules, probably up to molecular weights of 500,000; and the threshold molecular weight of the blood-lymph permselectivity of dextrans is approximately 17,500-39,000 in the small intestine and 10,500-17,500 in the large intestine.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Research Communications in Molecular Pathology and Pharmacology
K HigakiT Kimura
Journal of Bacteriology
S Rottem, S Razin
Journal of Controlled Release : Official Journal of the Controlled Release Society
A YamamotoS Muranishi
© 2021 Meta ULC. All rights reserved