Characteristics of early sacubitril/valsartan patients and considerations for studies in electronic health record data.

Journal of Comparative Effectiveness Research
Joshua J GagneShirley V Wang

Abstract

We examined characteristics of early sacubitril/valsartan users in a large US electronic health records database. We identified three cohorts of patients with heart failure (HF): sacubitril/valsartan patients with a prior HF diagnosis; patients with HF with reduced ejection fraction; and patients with HF treated with an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker and a β-blocker. Sacubitril/valsartan patients were younger than patients in the other cohorts; the mean age of sacubitril/valsartan patients increased by 2 years in the first 15 months of marketing. Most sacubitril/valsartan patients had prior use of HF treatment. Overall, sacubitril/valsartan patients resembled those in the HF with reduced ejection fraction cohort, and commonly used other drugs for HF.

References

Sep 18, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Joshua J GagneSebastian Schneeweiss
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
May 15, 2016·American Journal of Obstetrics and Gynecology·Justin R LappenDavid N Hackney
May 28, 2016·International Journal of Cardiology·Sadeer G Al-KindiChris T Longenecker
Jun 3, 2016·Digestive Diseases and Sciences·Emad Mansoor, Gregory S Cooper
Sep 11, 2016·Heart·Chang H KimGuilherme H Oliveira

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Citations

Jul 11, 2019·Journal of Comparative Effectiveness Research·Herminio Morillas-ClimentAlfonso Valle-Muñoz

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pharmacotherapy

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