Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis

Alimentary Pharmacology & Therapeutics
L J VineH R Dalton

Abstract

Abnormal liver blood tests are common in Epstein-Barr virus (EBV) infection, but symptomatic hepatitis is rare. The demographics, clinical features and outcome of EBV hepatitis are incompletely understood, particularly in the elderly people. To identify the demographics, presenting features and natural history of EBV hepatitis. Retrospective review of 1995 consecutive patients attending the jaundice hotline clinic over a 13-year period. Data collected included demographic information, presenting features, clinical and laboratory parameters, radiology imaging and clinical outcome. Seventeen of 1995 (0.85%) had EBV hepatitis. The median age was 40 years (range 18-68 years). Ten of 17 (59%) patients were aged >30 years, and seven of 17 (41%) patients were aged ≥60 years. Fifteen of 17 (88%) patients presented with clinical/biochemical evidence of jaundice. Seventeen of 17 (100%) patients had a serum lymphocytosis at presentation. 2/17 (12%) patients with EBV hepatitis presented with the classical features of infectious mononucleosis (fever, sore throat and lymphadenopathy). Splenomegaly was present in 15/17 (88%) of patients. Symptoms lasted for a median 8 weeks (range 1-12 weeks). Three of 17 (18%) patients required a brief hospi...Continue Reading

References

Apr 1, 1988·Archives of Disease in Childhood·N J Shaw, J H Evans
Sep 1, 1995·Journal of Hepatology·G V PapatheodoridisN C Tassopoulos
Sep 15, 1998·Journal of Gastroenterology and Hepatology·Y EdouteN Assy
Jun 3, 2000·Current Opinion in Pediatrics·H B Jenson
Jul 27, 2002·BMJ : British Medical Journal·Jonathan MitchellHarry Dalton
May 22, 2003·Digestive Diseases and Sciences·Tamim B Hinedi, Raymond S Koff
Mar 24, 2006·Journal of Hepatology·Uta DrebberHans P Dienes
Oct 28, 2006·Medicinski pregled·Predrag CanovićZeljko Mijailović
Sep 14, 2007·Alimentary Pharmacology & Therapeutics·H R DaltonR P Bendall
Sep 9, 2008·Annals of Diagnostic Pathology·Francesca SánchezSergi Serrano
Dec 2, 2009·The Korean Journal of Internal Medicine·Min-Jung KangKyu Won Chung
May 3, 2012·Lancet·Nassim KamarHarry R Dalton

❮ Previous
Next ❯

Citations

Jan 28, 2014·Digestive Diseases and Sciences·Jessica L MellingerRobert J Fontana
Mar 4, 2014·Current Infectious Disease Reports·Harry R DaltonAnnemiek A van der Eijk
Oct 12, 2013·Journal of Medical Virology·Katrine Cauldwell, Roger Williams
Dec 13, 2012·Journal of Viral Hepatitis·L Scobie, H R Dalton
Dec 18, 2014·Future Microbiology·Harry R DaltonJacques Izopet
Jun 25, 2016·Case Reports in Pediatrics·Amr Matoq, Asma Salahuddin
Apr 28, 2017·Scandinavian Journal of Gastroenterology·Hilmar LeonardssonEinar S Björnsson
Oct 3, 2014·World Journal of Hepatology·Masami MinemuraYukihiro Shimizu
Jun 21, 2018·Journal of Digestive Diseases·Arish NoorGeorge Y Wu
Aug 29, 2013·Current Opinion in Infectious Diseases·Harry R DaltonRichard P Bendall
Sep 2, 2019·BMJ Case Reports·Robin G ManappallilBlessy Josphine
Feb 18, 2020·Clinical Practice and Cases in Emergency Medicine·Jessica Herold, Felipe Grimaldo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.