PMID: 698234Sep 28, 1978Paper

Characteristics of fatty acid oxidation in rat liver homogenates and the inhibitory effect of malonyl-CoA

Biochimica Et Biophysica Acta
J D McGarryD W Foster

Abstract

Experiments were carried out to study the control of fatty acid oxidation and ketogenesis in rat liver homogenates. In contrast to findings with the perfused liver, rates of fatty acid oxidation were high and equal in liver homogenates from fed and fasted animals. No difference in apparent Km values for oleate, ATP, coenzyme A or carnitine could be detected in the two types of homogenate. Over the concentration range 20--40 micron, malonyl-CoA inhibited oleate oxidation by 50--75%. The fact that the inhibitory effect could be removed by pre-treatment with alkali or fatty acid synthetase indicated that the inhibitory molecule was malonyl-CoA rather than a contaminant. The effect was readily reversible and appeared to be competitive with oleyl-CoA. Malonyl-CoA also inhibited oleate oxidation in homogenates of heart and kidney cortex but this is unlikely to have physiological relevance since, in contrast to liver, neither tissue contains an active cytosolic pathway for the generation of malonyl-CoA and the synthesis of fatty acids.

References

Apr 1, 1977·Archives of Internal Medicine·J D McGarry, D W Foster
Jul 1, 1977·The Journal of Clinical Investigation·J D McGarryD W Foster
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J D McGarryD W Foster
May 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·E RyderM D Lane
Sep 8, 1970·Biochimica Et Biophysica Acta·E M Wit-PeetersH L Elenbaas
Jul 1, 1970·European Journal of Biochemistry·S Skrede, J Bremer
Apr 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·E J MASORO, E PORTER

❮ Previous
Next ❯

Citations

Feb 1, 1993·Progress in Neurobiology·A Nehlig, A Pereira de Vasconcelos
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·J HaK H Kim
Aug 1, 1988·Mechanisms of Ageing and Development·S MoriS Yoshida
Apr 24, 2016·Cardiovascular Drugs and Therapy·Cher-Rin ChongJohn D Horowitz
Jul 17, 2008·Archives of Physiology and Biochemistry·Janos KernerCharles L Hoppel
Oct 1, 1980·Archives of Biochemistry and Biophysics·J D Bergstrom, R C Reitz
Apr 19, 2008·IUBMB Life·Victor A Zammit
Aug 1, 1984·Journal of Dairy Science·R J AielloJ H Herbein
Jun 1, 1983·The Proceedings of the Nutrition Society·V A Zammit
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·J ChenS Zou
Apr 3, 2012·Acta Physiologica·J S V LallyA Bonen
Jul 12, 2020·The Journal of Biological Chemistry·Peng Zhao, Alan R Saltiel
Dec 26, 2009·Obesity·Tong WangBarbara E Corkey
Jul 30, 2020·The Journal of Biological Chemistry·James R KrycerDavid E James
Aug 1, 1995·The American Journal of Physiology·A K SahaN B Ruderman
Feb 15, 1982·Biochimica Et Biophysica Acta·J H Veerkamp, H T Van Moerkerk
Oct 11, 1983·Biochimica Et Biophysica Acta·J H VeerkampV W Van Hinsbergh
Jan 1, 1983·Metabolism: Clinical and Experimental·F DemaugreJ P Leroux
Aug 10, 2021·Environmental Science and Pollution Research International·Patience E ObiweluozoArinze I Onwurah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.