Characteristics of fecal microbial communities in patients with non-anastomotic biliary strictures after liver transplantation

World Journal of Gastroenterology : WJG
Jing ZhangYi Lv

Abstract

To explore the possible relationship between fecal microbial communities and non-anastomotic stricture (NAS) after liver transplantation (LT). A total of 30 subjects including 10 patients with NAS, 10 patients with no complications after LT, and 10 non-LT healthy individuals were enrolled. Fecal microbial communities were assessed by the 16S rRNA gene sequencing technology. Different from the uncomplicated and healthy groups, unbalanced fecal bacterium ratio existed in patients with NAS after LT. The results showed that NAS patients were associated with a decrease of Firmicutes and Bacteroidetes and an increase of Proteobacteria at the phylum level, with the proportion-ratio imbalance between potential pathogenic families including Enterococcaceae, Streptococcaceae, Enterobacteriaceae, Pseudomonadaceae and dominant families including Bacteroidaceae. The compositional shifts of the increase of potential pathogenic bacteria as well as the decrease of dominant bacteria might contribute to the incidence of NAS.

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Citations

Jul 9, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Saranya SivarajMamatha Bhat
Oct 13, 2021·Current Opinion in Organ Transplantation·Nikki Duong, Jasmohan Singh Bajaj

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Methods Mentioned

BETA
PCR
electrophoresis
PCA

Software Mentioned

SPSS
QIIME
R R
pcaMethods

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