PMID: 2478213Aug 1, 1989Paper

[Characteristics of GABA-activated chlorine channels in hippocampal slices].

Biulleten' eksperimental'noĭ biologii i meditsiny
V S Vorob'ev

Abstract

A new preparation for patch clamp study of ion channels is reported. Transverse hippocampal slices were incubated in normal physiological solution for 8 h. When necessary they were transferred into the experimental chamber and torn immediately on the level of pyramidal layer. The neurons, visible on the torn surface, were capable of forming tight glass-membrane contacts. Preliminary measurements of GABA induced chlorine currents were performed by patch-lamp technique. There were at least two types of patches with different properties, activated by low and high GABA concentrations. The influence of diazepam on GABA sensitivity was also examined. The conclusion was made that diazepam enhanced the channel activity without affecting channel properties.

References

Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J Bormann, D E Clapham
Apr 22, 1988·Neuroscience Letters·N AkaikeO A Krishtal

❮ Previous
Next ❯

Citations

Jul 1, 1991·Journal of Neuroscience Methods·V S Vorobjev
Jan 1, 1992·Brain Research. Molecular Brain Research·E LouisetL Cazin
Jan 1, 1995·Neurochemistry International·H K Kimelberg
Mar 1, 1994·Progress in Neurobiology·K Kaila
Jul 31, 1990·Neuroscience Letters·G von BlankenfeldH Kettenmann
Feb 28, 1994·Neuroscience Letters·A M Butt, J Jennings
Jun 1, 1993·Neuroscience·M NilssonE Hansson
Oct 1, 1994·Neuroscience·I I Grichtchenko, M Chesler
Oct 1, 1991·Current Opinion in Neurobiology·B A Barres
Dec 31, 2003·Neuroscience·I Timofeev, M Steriade
Apr 27, 2000·Neuroscience and Biobehavioral Reviews·P R LamingK Ng
Apr 13, 2000·Brain Research. Brain Research Reviews·A Verkhratsky, C Steinhäuser
Sep 5, 1998·Brain Research. Developmental Brain Research·G H ClaytonR L Smith
Mar 17, 2000·Brain Research. Molecular Brain Research·M ZhouH K Kimelberg
Mar 25, 2000·Neurochemistry International·P R Laming
Mar 25, 2000·Neurochemistry International·W Walz
Mar 1, 1997·Progress in Neurobiology·J T Porter, K D McCarthy
Jul 29, 1998·Neuroscience·F Frischknecht, A D Randall
Jan 1, 1992·The European Journal of Neuroscience·C. SteinhäuserH. Kettenmann
Jun 1, 1995·The European Journal of Neuroscience·A PastorH Kettenmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.