Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
N ToftePeter Rossing

Abstract

To compare clinical baseline data in individuals with Type 2 diabetes and normoalbuminuria, who are at high or low risk of diabetic kidney disease based on the urinary proteomics classifier CKD273. We conducted a prospective, randomized, double-blind, placebo-controlled international multicentre clinical trial and observational study in participants with Type 2 diabetes and normoalbuminuria, stratified into high- or low-risk groups based on CKD273 score. Clinical baseline data for the whole cohort and stratified by risk groups are reported. The associations between CKD273 and traditional risk factors for diabetic kidney disease were evaluated using univariate and logistic regression analysis. A total of 1777 participants from 15 centres were included, with 12.3% of these having a high-risk proteomic pattern. Participants in the high-risk group (n=218), were more likely to be men, were older, had longer diabetes duration, a lower estimated GFR and a higher urinary albumin:creatinine ratio than those in the low-risk group (n=1559, P<0.02). Numerical differences were small and univariate regression analyses showed weak associations (R2 < 0.04) of CKD273 with each baseline variable. In a logistic regression model including clinical...Continue Reading

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Citations

Jan 12, 2019·Proteomics. Clinical Applications·Frederik Persson, Peter Rossing
Feb 16, 2019·Proteomics. Clinical Applications·Alberto Ortiz
Feb 1, 2019·Proteomics. Clinical Applications·Tianlin He
Jan 24, 2019·Current Opinion in Nephrology and Hypertension·Carmine Zoccali, Francesca Mallamaci
Oct 11, 2019·Current Opinion in Nephrology and Hypertension·Marie Frimodt-MøllerPeter Rossing
Nov 27, 2019·European Journal of Preventive Cardiology·Giel NijpelsPetra J Elders
Dec 28, 2019·International Journal of Molecular Sciences·Vittorio SirolliMario Bonomini
Jan 11, 2020·Critical Care : the Official Journal of the Critical Care Forum·Esther Nkuipou-KenfackUNKNOWN French and European Outcome Registry in Intensive Care Unit Investigators
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Oct 28, 2020·The Cochrane Database of Systematic Reviews·Edmund Ym ChungGiovanni Fm Strippoli
Apr 16, 2021·Endocrinology, Diabetes & Metabolism·Rachel AdamsGiuseppe N Giordano
Jun 1, 2021·Journal of Cardiovascular Pharmacology·Kristin WatsonChristine E Shulenberger
Jul 1, 2021·Expert Review of Proteomics·Qi Wu, Robert A Fenton
Sep 15, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Sam HodgsonHajira Dambha-Miller

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