Characteristics of high-titer IgG antiphospholipid antibody in systemic lupus erythematosus patients with and without fetal death

Arthritis and Rheumatism
T QamarM D Lockshin

Abstract

Although high-titer IgG antiphospholipid antibody (aPL) is a predictor of mid-pregnancy fetal death in women with systemic lupus erythematosus (SLE), some SLE patients with high-titer aPL carry pregnancies normally, and to term. To determine potential antibody differences between IgG aPL-positive women with and without fetal death, we studied aPL isotype, subclass, anticoagulant activity, phospholipid specificity, and antibody avidity in selected sera from pregnant SLE patients with high-titer IgG aPL. For controls, we selected sera from pregnant SLE patients who had negative results on tests for IgG aPL (with and without fetal loss). None of the specified antibody characteristics distinguished between the aPL-positive patient groups, nor were other specificities defined in IgG aPL-negative sera from women with fetal death. Although high-titer aPL is a good predictor of fetal death, currently known characteristics, other than a high titer of aPL, do not identify which women will experience this complication.

References

Feb 1, 1989·Annals of the Rheumatic Diseases·H L StaubG R Hughes
Feb 1, 1989·American Journal of Obstetrics and Gynecology·M D LockshinT Qamar
Oct 4, 1988·Journal of Immunological Methods·M Stenberg, H Nygren
Apr 1, 1987·Arthritis and Rheumatism·M D Lockshin
Nov 10, 1988·Journal of Immunological Methods·A E Gharavi, M D Lockshin
May 1, 1988·Journal of Clinical Immunology·M D LockshinM P Best
Jan 1, 1987·Annals of the Rheumatic Diseases·A E GharaviG R Hughes

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Citations

Jun 9, 1998·Journal of Reproductive Immunology·D W Branch
Oct 11, 2003·Autoimmunity Reviews·Gian Domenico SebastianiMauro Galeazzi
Mar 1, 1992·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Meurer, K Degitz
May 23, 1992·BMJ : British Medical Journal·H E Emson
Jan 1, 1993·Ocular Immunology and Inflammation·L BieloryL Frohman
Feb 13, 2013·American Journal of Reproductive Immunology : AJRI·Shanmugam VelayuthaprabhuGovindaraju Archunan
Oct 1, 1992·The American Journal of Medicine·L H SilveiraL R Espinoza
Oct 9, 2013·The Kaohsiung Journal of Medical Sciences·Yun YeYa-Jun Li
Feb 1, 1992·Lupus·L R SammaritanoA E Gharavi
Feb 1, 1997·Rheumatic Diseases Clinics of North America·A LynchW Emlen
Aug 1, 1994·Lupus·E N Harris, S Pierangeli
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·G J RinkelR J Hené
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M Celli, A E Gharavi
Oct 1, 1996·Lupus·L R Sammaritano
Nov 19, 1997·Arthritis and Rheumatism·L R SammaritanoJ E Salmon
Dec 16, 1998·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·J AckermanE Gilbert-Barness
Oct 1, 1992·American Journal of Reproductive Immunology : AJRI·E N Harris, S Pierangeli
Oct 1, 1990·Seminars in Arthritis and Rheumatism·L R SammaritanoM D Lockshin

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