PMID: 9427460Jan 14, 1998Paper

Characteristics of human immunodeficiency virus-infected children at the time of death: an experience in the 1990s

The Pediatric Infectious Disease Journal
R Johann-LiangG J Noel

Abstract

To describe the changes in the characteristics of human immunodeficiency virus (HIV)-related deaths in children with perinatally acquired infection. A retrospective review of all deaths that occurred in HIV-infected children managed at The New York Hospital-Program for Children with AIDS during a 7-year period from January, 1990, to December, 1996. Differences in the characteristics at death between 15 children who died in 1990 and 10 children who died in 1996 were analyzed. Fifty-eight deaths in our cohort of HIV-infected children were identified during the 7-year period. The mean age at death was 4.43 years. Sixty-nine percent of children were black, 55% were male and 94% were receiving Medicaid. The mean weight/age Z score was -3.9 and the mean CD4 index was 0.067 with 65% having <50 CD4 cells/microl at the time of death (TOD). The most common organ/organ systems to be involved at the TOD were lung (78%) and central nervous system (61%). Mycobacterium avium complex (MAC) was the most common isolate at the TOD (26%) followed by Pneumocystis carinii (20%) and Pseudomonas aeruginosa (17%). The leading non-infectious cause of death was cardiac failure (9%). Comparison of the characteristics at the TOD between 1990 and 1996 revea...Continue Reading

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Citations

Dec 11, 1999·Mycoses·S CimermanA L Colombo
May 22, 2001·AIDS Patient Care and STDs·C L Lee, R Johann-Liang
Jan 30, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Yinhong ChenPaul F McDonagh
Oct 18, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bill G KapogiannisMarc Bulterys
Sep 3, 1998·The Pediatric Infectious Disease Journal·R Johann-LiangG Noel
Dec 24, 2013·AIDS·Surbhi ModiUNKNOWN Child Survival Working Group of the Interagency Task Team on the Prevention and Treatment of HIV Infection in Pregnant Women
Jul 12, 2012·AIDS·Kunjal PatelUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials 219219C Study Team
Dec 26, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael T BradyUNKNOWN Pediatric AIDS Clinical Trials Group219/219C Team
Aug 15, 2002·Paediatric Drugs·Patrick J Gavin, Ram Yogev
Oct 3, 2000·Progress in Cardiovascular Diseases·W Lewis
Sep 28, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·George R SeageWayne M Dankner

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