Characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases

World Journal of Gastroenterology : WJG
Yusuke SekinoAtsushi Nakajima


To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. Between January 2000 and December 2010, 31 patients (13 males and 18 females) were diagnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without C...Continue Reading


Jan 1, 1988·Annual Review of Medicine·S Anuras
Jan 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·C D RudolphJ A Vanderhoof
Feb 25, 1998·QJM : Monthly Journal of the Association of Physicians·P F Chinnery, D M Turnbull
Jun 24, 1999·Cellular and Molecular Life Sciences : CMLS·M G Hanna, I P Nelson
Jun 27, 2003·The New England Journal of Medicine·Salvatore DiMauro, Eric A Schon
Jan 14, 2004·Diseases of the Colon and Rectum·Abdulhakim GliaGreger Lindberg
Dec 25, 2004·Medical Hypotheses·Jeffrey Gilbert, Jamal A Ibdah
Apr 19, 2005·Neuromuscular Disorders : NMD·T PulkesM G Hanna
Jan 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Dwight H SuttonJohn M Wo
Feb 14, 2006·Gastroenterology·Frances L Connor, Carlo Di Lorenzo
May 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Y YamanakaT Hattori
Sep 26, 2006·Casopís lékar̆ů c̆eských·T HonzíkJ Zeman
Jun 30, 2010·European Journal of Pediatrics·Zeren BarişAlev Hasanoğlu
Jul 16, 2011·Methods in Molecular Biology·Carla Giordano, Giulia d'Amati
Sep 22, 2011·Brain : a Journal of Neurology·Caterina GaroneMichio Hirano
Sep 24, 2011·Journal of Postgraduate Medicine·A SharmaS T Teelucksingh
Feb 2, 2012·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Vanesa Camarero-TemiñoPedro Abaigar-Luquin


Apr 10, 2016·Developmental Biology·Allan M GoldsteinRoberto De Giorgio
Jul 28, 2016·Annals of Neurology·Yi Shiau NgGráinne S Gorman
Sep 1, 2015·Journal of Neurology·Yi Shiau Ng, Doug M Turnbull
Mar 14, 2017·Therapeutic Advances in Gastroenterology·Josef Finsterer, Marlies Frank
Aug 28, 2018·Clinical Case Reports·Toshiyuki ItaiYu Tsuyusaki
Oct 31, 2018·Journal of Clinical Medicine·Massimiliano FilostoAlessandro Padovani
Jul 28, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sumit ParikhP F Chinnery
Feb 21, 2020·Current Gastroenterology Reports·Zorisadday Gonzalez, Richard McCallum

Related Concepts

Intestinal Diseases
Visceral Myopathy
Retrospective Studies
Mitochondrial Encephalomyopathies
Melas Syndrome
Chronic Progressive External Ophthalmoplegia
Oxidative Phosphorylation Deficiencies
Acidosis, Lactic
Amaranth Dye

Related Feeds


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.