Characteristics of ionic transport processes in fish intestinal epithelial cells

Bio Systems
L MovileanuP T Frangopol

Abstract

A general mathematical version of the cell model of a leaky epithelium for the NaCl absorption is presented, analysed and integrated numerically. The model consists in the adequate differential equations that describe the rate of change of the intracellular ion concentrations and are expressed in strict accordance with the law of mass conservation. The model includes many state variables representing ion concentrations, the cell volume, and membrane potentials. Ion movements are described by the Michaelis-Menten kinetics or by the constant field flux equation (Goldman-Hodgkin-Katz). In this paper, we model the intracellular ion concentrations, change in the cell volume, the transmembrane flux and membrane potentials of intestinal epithelium of both fresh water and sea water fish, and generate several simulations (in both the steady state and the transient state analysis) that appear to accord with prior experimental data in this area. For the ion movements of the sea water fish intestine, there were included a Na+/K+ pump, a K(+)-Cl- symport system, the K+ and Cl- channels in the basolateral membrane, whereas a Na(+)-K(+)-2Cl- cotransporter for NaCl absorption and K+ channels are located in the apical membrane. In the fresh wat...Continue Reading

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Citations

Feb 16, 2005·The Journal of Membrane Biology·N C AdragnaP K Lauf
Apr 1, 1999·Journal of Biochemical and Biophysical Methods·L Movileanu
Sep 6, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Julian G RubinoChris M Wood

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