Characteristics of luteinizing hormone secretion in younger versus older premenopausal women

American Journal of Obstetrics and Gynecology
D W MattW S Evans

Abstract

The objectives of this study were to document specific attributes of pulsatile luteinizing hormone secretion in middle-aged women before discernible alterations in their menstrual cycles and to compare the results to corresponding data obtained in younger women. After documenting normal cycle length, biphasic basal body temperatures, and normal midluteal progesterone in younger and middle-aged women during an initial cycle, daily blood samples and samples withdrawn at 10-minute intervals for 8 hours during the midfollicular phase were obtained during a subsequent cycle. Assessment of luteinizing hormone pulses with the pulse detection algorithm Cluster demonstrated a prolonged interpulse interval and increased pulse width in the older women. Assessment of luteinizing hormone secretory bursts and half-life with the deconvolution analysis procedure demonstrated a prolonged interburst interval and half-life in the older women. Appraisal of approximate entropy revealed greater orderliness of luteinizing hormone release in the older women. Middle-aged women exhibit alterations in hypothalamic-pituitary function that may account in part for age-related changes in reproductive potential.

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Citations

May 23, 2008·Biology of Reproduction·Margaret L Walker, James G Herndon
Aug 5, 2005·Steroids·Darrell W Brann, Virendra B Mahesh
Jun 1, 2005·General and Comparative Endocrinology·N A CicconeI C Dunn
Sep 2, 2008·Biometrics·Nichole E CarlsonMorton B Brown
Oct 27, 2004·Endocrinology and Metabolism Clinics of North America·Janet E Hall
Jan 26, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Luigi DevotoPaulina Kohen
Sep 25, 2001·American Journal of Obstetrics and Gynecology·J Klein, M V Sauer
Nov 7, 2006·Molecular and Cellular Endocrinology·Steven BirkenGeorge Taliadouros
Dec 10, 2008·Molecular and Cellular Endocrinology·Jodi L Downs, Phyllis M Wise
Sep 1, 2017·Aging Cell·Takashi UmeharaMasayuki Shimada
Jun 16, 1999·Endocrine Reviews·P M WiseK L Rosewell
Jul 11, 2009·Endocrine Reviews·F J BroekmansB C Fauser
Jun 26, 2015·Physiological Reviews·Yuko HaraJohn H Morrison
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J D VeldhuisS M Pincus
Jul 3, 2002·Experimental Biology and Medicine·Susanna J ParkGerson Weiss
Dec 22, 1999·The American Journal of Physiology·P M Wise
Aug 24, 2005·Gender Medicine·Habib U Rehman, Ewan A Masson

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