Characteristics of lysine transport across the serosal pole of the anuran small intestine

The Journal of Physiology
C Cheeseman

Abstract

The transport of the dibasic amino acid L-lysine across the serosal pole of the intestinal epithelium has been studied using the vascularly perfused anuran small intestine. The exit of pre-loaded lysine into the vascular bed was inhibited by L-ornithine (2 mM) and L-arginine (10 mM) when pulsed through the lumen during the wash-out, while 2-aminoisobutyric acid (AIB), L-histidine, L-citrulline and L-cystine had no effect. Luminal L-leucine and L-alanine at a concentration of 10 mM markedly stimulated the unloading of lysine into the vascular bed and sarcosine, L-proline and beta-alanine also did so to a lesser extent. The instantaneous rate constant for lysine exit into the vascular bed was increased by the presence of L-arginine, L-ornithine, L-citrulline, L-histidine, AIB, L-leucine and L-alanine at a concentration of 10 mM in the vascular bed. L-proline had no effect. The simultaneously measured efflux of lysine into the lumen was unaffected by the presence of the other amino acids in the vascular bed. The uptake of lysine into the epithelium from the vascular bed was accelerated by L-ornithine and slightly by L-arginine when they were present in the lumen, while L-leucine, L-alanine, beta-alanine, L-proline, L-citrulline, s...Continue Reading

Citations

Mar 31, 2004·Molecular Genetics and Metabolism·Manuel PalacínAntonio Zorzano
Jan 1, 1990·The International Journal of Biochemistry·J M Argiles, F J Lopez-Soriano
Jan 15, 2008·Experimental Physiology·C A R Boyd
Jan 16, 2008·Physiological Reviews·Stefan Bröer
Oct 28, 1998·Physiological Reviews·M PalacínA Zorzano
Jan 1, 1991·Progress in Biophysics and Molecular Biology·C I Cheeseman
Jan 26, 1987·Biochimica Et Biophysica Acta·S DaviesC I Cheeseman
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·S J ReshkinC Storelli
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·C F Nassar

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