PMID: 139198Mar 1, 1977Paper

Characteristics of nondepolarizing neuromuscular block: (I) post-junctional block by alpha-bungarotoxin

Canadian Anaesthetists' Society Journal
C LeeR L Katz

Abstract

The characteristics of neuromuscular block produced by alpha-bungarotoxin, a post-junctionally active polypeptide toxin purified from snake venoms, have been studied in vivo in 12 anaesthetized cats, using the sciatic nerve-tibialis anterior muscle preparation. The onset of the neuromuscular block was slow and without fasciculation. The block was persitently progressive. The time course of the block depended on the dosage. In general, 0.1 mg/kg of alpha-BuTX appeared to approximate the threshold dosage while 0.2 mg/kg completely eliminated the twitch response in 2-5 hours. No recovery was observed in 8-30 hours. Larger doses accelerated the progression of the block. During the block, tetanic contractions and train-of-four twitches did not fade. The post-tetanic twitches were markedly facilitated. The block was antagonized by edrophonium, neostigmine, pyridostigmine, and succinylcholine, but the antagonism was less effective and shorter-lasting than that observed on curare-block, and the block always resumed the projected progression. Attempts were made to explain the observed difference between alpha-BuTX- and dTc-induced neuromuscular blocks by the practically permanent nature of block and the purely post-junctional site of ac...Continue Reading

Associated Clinical Trials

Aug 17, 2020·Mohamed Tharwat Hegazy

References

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Citations

Dec 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ShiraishiS Ogawa
Jan 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S K TsaiC M Lee
Jan 25, 1990·European Journal of Pharmacology·R J BradleyW C Chau
Aug 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·K BlountI G Marshall
Oct 17, 2013·PLoS Neglected Tropical Diseases·Udaya K RanawakaH Janaka de Silva
Jan 1, 1990·Annals of the New York Academy of Sciences·W C BowmanI G Marshall
Nov 1, 1986·British Journal of Pharmacology·A J Gibb, I G Marshall
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·A Mark Evans
Jan 1, 1984·Annales Françaises D'anesthèsie Et De Rèanimation·J Kienlen

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