Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy

Cancer
Akiko MakiyamaTakeshi Okanoue

Abstract

The objective of the current study was to determine the characteristic features of sustained responders who develop hepatocellular carcinoma after treatment with interferon for chronic hepatitis C. This study included 3626 patients with chronic hepatitis C who had received interferon monotherapy. Cox proportional hazards analysis was used to compare sustained responders who did and did not develop hepatocellular carcinoma, and nonsustained responders who developed hepatocellular carcinoma in a multicenter, retrospective cohort study. Among 1197 sustained responders, 27 patients developed hepatocellular carcinoma (2.3%). Compared with sustained responders who did not develop hepatocellular carcinoma, patients who developed disease more often were male (P = 0.0212), were older (P = 0.0068), and had advanced-stage histologic disease before interferon therapy (P = 0.0345). Conversely, compared with patients with hepatocellular carcinoma who were not sustained responders, patients who were sustained responders tended to be older at the time of the initiation of interferon therapy (P = 0.0552) and at the time hepatocellular carcinoma was detected (P = 0.0593), and they also were predominantly male (P = 0.0507). The histologic staging...Continue Reading

References

Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BarbaraA Mazziotti
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Dec 1, 1996·Journal of Gastroenterology and Hepatology·K R BalsonN D Yeomans
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A KasaharaK Okita
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H KhanC Liddle
Sep 28, 2000·European Journal of Gastroenterology & Hepatology·M YamadaS Yokoi
Aug 31, 2002·Journal of Gastroenterology·Soo Ryang KimYoshitake Hayashi
Dec 18, 2002·Annals of Internal Medicine·Alfredo AlbertiAngelo Gatta
Jan 25, 2003·Journal of Gastroenterology and Hepatology·Takeshi Okanoue, Yoshito Itoh

❮ Previous
Next ❯

Citations

Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brian L Pearlman, Nomi Traub
May 19, 2006·Journal of Gastroenterology and Hepatology·Masafumi IkedaHiroshi Watanabe
Feb 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Naota TauraMichio Sata
Oct 2, 2008·Internal Medicine·Miharu HirakawaHiromitsu Kumada
Dec 19, 2008·Digestive Diseases and Sciences·Yasushi TamuraUNKNOWN Niigata Liver Disease Study Group
Jun 1, 2012·Clinical Journal of Gastroenterology·Yoshimasa HashimotoKazuaki Chayama
Mar 30, 2016·Mediators of Inflammation·Akihiro TamoriNorifumi Kawada
Jul 24, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoki HiramatsuTetsuo Takehara
Mar 25, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshihiko TachiHidemi Goto
Oct 16, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Franco TrevisaniMauro Bernardi
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kazutoyo MoritaYoshihiko Maehara
May 22, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Takehiro HayashiSusumu Shiomi
Feb 12, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mika KurokawaNorio Hayashi
Nov 28, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi OkanoueHiromitsu Kumada
May 19, 2006·Journal of Gastroenterology and Hepatology·Hidenori Toyoda, Takashi Kumada
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Timothy R MorganUNKNOWN HALT-C Trial Group
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yao-Chun HsuChun-Ying Wu
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobuyoshi FukushimaMichio Sata
Oct 15, 2013·Journal of Gastroenterology and Hepatology·Yutaka NaritaTakafumi Ichida
Mar 20, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akihiro TamoriNorifumi Kawada
Jan 15, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Tram N Q PhamTomasz I Michalak
Jul 6, 2014·British Journal of Haematology·Caterina Borgna-PignattiStefano Volpato
Apr 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Izumi NamikiMasatoshi Kudo
Mar 15, 2005·Journal of Hepatology·Gregory T Everson
Nov 26, 2015·Gastroenterology Clinics of North America·Danielle M Tholey, Joseph Ahn
Jun 17, 2015·Cancer·Darrick K Li, Raymond T Chung
May 31, 2006·Expert Opinion on Pharmacotherapy·Mitsuhiko Moriyama, Yasuyuki Arakawa
Jun 11, 2015·Future Microbiology·Fabio Salvatore MacalusoAntonio Craxì
Apr 7, 2015·Seminars in Oncology·Yao-Chun HsuJaw-Town Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.