Characteristics of patients with hepatitis C virus-related chronic liver diseases just before the era of oral direct-acting antiviral therapy in Italy

European Journal of Gastroenterology & Hepatology
Evangelista SagnelliPiero Luigi Almasio

Abstract

In 2017, oral direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection became available free of charge for all HCV-RNA-positive patients, irrespective of their fibrosis stage. The aim of this study was to evaluate the characteristics of HCV-related chronic liver disease (CLD) in Italy just before the introduction of DAA therapy. Patients with CLD were enrolled in two national surveys conducted in 2001 and in 2014. The two surveys prospectively enrolled patients aged older than 18 years referring to Italian liver units throughout the country using a similar clinical approach and analytical methods. Out of the 12 564 patients enrolled, 8447 (67.3%) were anti-HCV-positive, with a decreasing trend from 69.0% in 2001 to 60.4% in 2014. During this period, an increasing trend over time was observed in the mean age of patients (55.6 vs. 59.1 years; P<0.01), in the proportion of patients with liver cirrhosis (19.4 vs. 28.2%; P<0.01), and in the circulation of genotype 4 (0 vs. 6.1%). The multiple logistic analysis showed that age older than 60 years, birth in southern Italy, and multiple etiology (HCV+hepatitis B virus or HCV+alcohol) are independent predictors of a likelihood of liver cirrhosis, whereas a hig...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerG Jensen
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
May 1, 2002·Journal of Clinical Microbiology·Matthias SchröterHeinz-Hubert Feucht
Feb 17, 2005·Journal of Medical Virology·Evangelista SagnelliPietro Filippini
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Savino BrunoUNKNOWN Italian Association of the Study of the Liver Disease (AISF)
Mar 21, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Slawomir ChlabiczLech Chyczewski
Feb 15, 2011·Journal of Hepatology·Mahmoud A KhattabSamuel S Lee
Feb 22, 2012·Annals of Internal Medicine·Kathleen N LyScott D Holmberg
Jul 24, 2012·JAMA : the Journal of the American Medical Association·Berkeley N LimketkaiMark S Sulkowski
Aug 30, 2012·Journal of Medical Virology·T StroffoliniUNKNOWN DAVIS Drug Addicted, HCV Prevalence in Italy an Epidemiological, Observational, Cross-Sectional, Multicenter Study Participa
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
May 17, 2013·The New England Journal of Medicine·T Jake Liang, Marc G Ghany
Jun 14, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Evangelista SagnelliUNKNOWN EPACRON study Group
Mar 21, 2017·Annals of Internal Medicine·Oluwaseun Falade-NwuliaMark S Sulkowski
Jun 24, 2017·Gastroenterology·Fasiha KanwalHashem B El-Serag

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

European Journal of Gastroenterology & Hepatology
Tommaso StroffoliniEPACRON study group
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Paul Y Kwo, A Joseph Tector
© 2022 Meta ULC. All rights reserved