Characteristics of patients with severe, uncontrolled, eosinophilic asthma enrolled in a French cohort

Journal of Asthma and Allergy
Michel AubierCaroline Fabry-Vendrand

Abstract

Benralizumab (Fasenra™) has recently been approved as add-on maintenance treatment for adult patients with severe eosinophilic asthma inadequately controlled despite high-dosage inhaled corticosteroids plus long-acting β2-agonists. We aimed to identify and describe the clinical characteristics and disease burden of patients with severe, uncontrolled, eosinophilic asthma in France who may be eligible for treatment with benralizumab. This was a retrospective analysis of a prospective, noninterventional, observational study of patients in France enrolled in the Asthma and Bronchial Obstruction Cohort (COBRA). First, we selected adult patients with severe asthma, a documented blood eosinophil count, 12 months of baseline data, and 12 months of follow-up data. Of these study-eligible patients, we next determined the prevalence and described the clinical characteristics and disease burden of patients who would be eligible to receive benralizumab, namely those with ≥2 asthma exacerbations in the previous 12 months and a blood eosinophil count ≥300/μL who were receiving high-dosage inhaled corticosteroids/long-acting β2-agonists. Of the 441 patients eligible for this study, 85 (19%) met the criteria for benralizumab therapy. At study i...Continue Reading

Clinical Trials Mentioned

NCT01928771
NCT01914757

Software Mentioned

Stata
R
COBRA
SIROCCO

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