PMID: 12760426May 23, 2003Paper

Characteristics of prolonged afterdischarges in children with malformations of cortical development

Journal of Child Neurology
Shiro ChitokuO Carter Snead

Abstract

We investigated aberrant cortical excitability in malformations of cortical development From subdural electrodes, we recorded afterdischarges lasting > or = 6 seconds in 12 of 13 patients with malformations of cortical development and 6 of 10 pediatric patients with nonmalformations of cortical development and reviewed amperage thresholds, distribution of afterdischarges, and motor responses. In patients with malformation of cortical development, motor response thresholds were high; afterdischarge and motor response thresholds, which essentially overlapped, inversely correlated with age (P < .01); afterdischarge thresholds declined with age; and 8 patients showed afterdischarges in remote sites. In nonmalformation of cortical development, afterdischarge thresholds did not significantly correlate with age; motor response thresholds tended to decline with age; and 2 patients had remote afterdischarges. Adolescent patients with malformations of cortical development had lower afterdischarge thresholds than adolescents with nonmalformation of cortical development (P < .05). From their high afterdischarge (and motor response) thresholds, we concluded that preadolescent patients with malformation of cortical development have less exci...Continue Reading

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Aug 2, 2002·Journal of Child Neurology·Takuya AkaiO Carter Snead

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Citations

Apr 21, 2007·Journal of the International Neuropsychological Society : JINS·Darren S KadisMary Lou Smith
Jul 4, 2006·Pediatric Neurology·Aimee F LuatHarry T Chugani
Mar 3, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Prasanna Jayakar
Sep 22, 2011·Epilepsia·Naranzogt TschuluunPhilip A Schwartzkroin
Oct 23, 2013·Epilepsia·Renzo GuerriniUNKNOWN Commission for Epilepsy Surgery of the Italian League Against Epilepsy
Jul 31, 2014·Annals of Neurology·Ludovic Franck PetitJean-Bernard Manent
Sep 3, 2014·CNS Neuroscience & Therapeutics·Françoise WatrinAlfonso Represa
Dec 29, 2020·Frontiers in Human Neuroscience·Krista M GrandeRavindra Arya

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