Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus

Medicine
Liang-Chen WangChunlin Li

Abstract

This study aims to compare the effect of repaglinide and metformin among Chinese patients with newly diagnosed diabetes, and explore the possible mechanisms by which repaglinide alters insulin secretion.Sixty subjects with glycated hemoglobin (HbA1c) < 10.0% were randomly selected to receive repaglinide or metformin monotherapy for 15 weeks. Blood glucose levels, glycemic variability, β-cell function, and first-phase insulin secretion were compared between these 2 groups at baseline and at 15 weeks. Mouse insulinoma (MIN-6) cells were divided into 3 groups: low glucose, high glucose, and repaglinide 50 nm groups. Cells and cell culture mediums were collected at different timepoints. The expression of pericentrin (PCNT), F-actin, and insulin were tested with immunofluorescence and enzyme-linked immunosorbent assay.All glycemic parameters and variability indexes significantly decreased from baseline to 15 weeks, while no significant difference was found between these 2 groups at baseline or at 15 weeks. Furthermore, there was no significant difference found in fasting insulin and postprandial insulin at baseline and at 15 weeks, while homeostasis model assessment β significantly increased. The first-phase glucose and insulin secr...Continue Reading

References

May 18, 2004·Molecular Biology of the Cell·Wendy C ZimmermanStephen J Doxsey
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Dec 3, 2009·The Journal of Cell Biology·Benedicte Delaval, Stephen J Doxsey
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Jan 29, 2011·Diabetes·Isabel Huang-DoranUNKNOWN Majewski Osteodysplastic Primordial Dwarfism Study Group
Nov 26, 2013·Archives of Medical Science : AMS·Rodolfo Guardado-MendozaFranco Folli
Apr 26, 2014·Current Medical Research and Opinion·Fu Sheng FangChun Lin Li
Jan 7, 2015·Pharmacogenomics·Miao ChenWeiping Jia
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Rosanna TortelliGiancarlo Logroscino
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang

❮ Previous
Next ❯

Citations

Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Aug 21, 2020·Drug Development and Industrial Pharmacy·Naazneen SurtiZubiya Surti

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.