Abstract
This study aims to compare the effect of repaglinide and metformin among Chinese patients with newly diagnosed diabetes, and explore the possible mechanisms by which repaglinide alters insulin secretion.Sixty subjects with glycated hemoglobin (HbA1c) < 10.0% were randomly selected to receive repaglinide or metformin monotherapy for 15 weeks. Blood glucose levels, glycemic variability, β-cell function, and first-phase insulin secretion were compared between these 2 groups at baseline and at 15 weeks. Mouse insulinoma (MIN-6) cells were divided into 3 groups: low glucose, high glucose, and repaglinide 50 nm groups. Cells and cell culture mediums were collected at different timepoints. The expression of pericentrin (PCNT), F-actin, and insulin were tested with immunofluorescence and enzyme-linked immunosorbent assay.All glycemic parameters and variability indexes significantly decreased from baseline to 15 weeks, while no significant difference was found between these 2 groups at baseline or at 15 weeks. Furthermore, there was no significant difference found in fasting insulin and postprandial insulin at baseline and at 15 weeks, while homeostasis model assessment β significantly increased. The first-phase glucose and insulin secr...Continue Reading
References
Mar 31, 1998·Diabetes·J FuhlendorffR D Carr
Jun 2, 2000·Diabetes Care·C B JuhlO Schmitz
May 18, 2004·Molecular Biology of the Cell·Wendy C ZimmermanStephen J Doxsey
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Nov 25, 2004·Diabetes·Ulrich QuastUlrich Russ
Dec 3, 2009·The Journal of Cell Biology·Benedicte Delaval, Stephen J Doxsey
Jan 12, 2010·Diabetes Research and Clinical Practice·Yan LiZuzhi Fu
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Aug 3, 2010·PloS One·Agata JurczykRita Bortell
Jan 29, 2011·Diabetes·Isabel Huang-DoranUNKNOWN Majewski Osteodysplastic Primordial Dwarfism Study Group
Mar 8, 2013·PloS One·Linong JiZhengying Zhu
Mar 28, 2013·Diabetes Technology & Therapeutics·Guang YangHui Tian
Nov 26, 2013·Archives of Medical Science : AMS·Rodolfo Guardado-MendozaFranco Folli
Apr 4, 2014·European Journal of Endocrinology·Fu-Sheng FangLin Li
Apr 26, 2014·Current Medical Research and Opinion·Fu Sheng FangChun Lin Li
Apr 29, 2014·Journal of Diabetes Research·J MaW Liu
Jan 7, 2015·Pharmacogenomics·Miao ChenWeiping Jia
Jun 18, 2015·PloS One·Yuan ZuXiangmei Chen
Jan 16, 2016·Journal of Diabetes Research·Guang YangXiaoling Cheng
Apr 21, 2016·The Biochemical Journal·Seo-Yun YangKong-Joo Lee
Apr 23, 2016·Biochimica Et Biophysica Acta·Aurore QuinaultCecile Tourrel-Cuzin
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Rosanna TortelliGiancarlo Logroscino
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Citations
Dec 4, 2019·Frontiers in Pharmacology·Tao WangXiao-Xing Yin
Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Aug 21, 2020·Drug Development and Industrial Pharmacy·Naazneen SurtiZubiya Surti
Oct 18, 2020·Microorganisms·Deng LinLiang Zhao