Characteristics of resting-state functional connectivity in older adults after the PICMOR intervention program: a preliminary report

BMC Geriatrics
Hikaru SugimotoMihoko Otake-Matsuura

Abstract

The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. We found higher rsFC in INT than in CONT between the left inferior fron...Continue Reading

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Software Mentioned

INT
CONN
Photo Integrated Conversation Moderated by Robots ( PICMOR )
PICMOR
PVFT
MATLAB

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