PMID: 9438536Jan 23, 1998Paper

Characteristics of serum hyaluronate concentrations in patients with alcoholic liver disease

Alcoholism, Clinical and Experimental Research
M TsutsumiH Kawahara

Abstract

It has been reported that serum hyaluronate [hyaluronic acid (HA)] concentrations are increased in liver diseases, especially in alcoholic liver disease (ALD). However, the characteristics of serum HA concentration in patients with ALD have not been studied. In this study, first, we measured serum HA concentrations in patients with different stages of both ALD and non-ALD to clarify the characteristics of serum HA concentration in patients with ALD. Second, we measured serum HA concentrations in patients with ALD sequentially after abstinence. We also measured serum HA concentrations in patients with chronic type C hepatitis before and after treatment with interferon. Finally, we analyzed the relationship between serum HA concentrations and the contents of type IV collagen and laminin in the livers of both ALD and non-ALD patients. Serum HA concentrations in liver disease were higher than the cut-off value, and increased significantly (p < 0.001) in parallel with the progression of hepatic fibrosis in both ALD and non-ALD patients. Serum HA concentrations in patients actively drinking with ALD were significantly higher (p < 0.001) than those in non-ALD. After 4 weeks of abstinence, these concentrations fell to the levels of non...Continue Reading

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Citations

Dec 4, 2003·The International Journal of Biochemistry & Cell Biology·Joseph GeorgeShujiro Takase
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sylvie NaveauThierry Poynard
Oct 10, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Roberto CatanzaroFrancesco Marotta
Mar 4, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paramananda SaikiaLaura E Nagy
Sep 1, 1999·European Journal of Clinical Investigation·T OgataS Aoyagi
Sep 14, 2001·Journal of Gastroenterology and Hepatology·M TsutsumiS Takase
Jul 5, 2018·Alimentary Pharmacology & Therapeutics·N PlevrisP C Hayes
Nov 13, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jennifer E RowleyMichele T Pritchard

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