Abstract
It has been reported that serum hyaluronate [hyaluronic acid (HA)] concentrations are increased in liver diseases, especially in alcoholic liver disease (ALD). However, the characteristics of serum HA concentration in patients with ALD have not been studied. In this study, first, we measured serum HA concentrations in patients with different stages of both ALD and non-ALD to clarify the characteristics of serum HA concentration in patients with ALD. Second, we measured serum HA concentrations in patients with ALD sequentially after abstinence. We also measured serum HA concentrations in patients with chronic type C hepatitis before and after treatment with interferon. Finally, we analyzed the relationship between serum HA concentrations and the contents of type IV collagen and laminin in the livers of both ALD and non-ALD patients. Serum HA concentrations in liver disease were higher than the cut-off value, and increased significantly (p < 0.001) in parallel with the progression of hepatic fibrosis in both ALD and non-ALD patients. Serum HA concentrations in patients actively drinking with ALD were significantly higher (p < 0.001) than those in non-ALD. After 4 weeks of abstinence, these concentrations fell to the levels of non...Continue Reading
References
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R GibsonF J Dudley
Dec 22, 1990·Lancet·L MimmsJ Zeldis
Mar 1, 1990·Journal of Electron Microscopy Technique·B Le BailC Balabaud
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BabbsT W Warnes
May 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·K ChichibuM M Yokoyama
Feb 1, 1989·The Biochemical Journal·C T McGaryP H Weigel
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergA Vahlquist
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T FrébourgJ Bourreille
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Engström-LaurentT Schröder
Jan 1, 1985·Cell and Tissue Research·J R FraserG B Ryan
Aug 1, 1981·Seminars in Liver Disease·H PopperM A Gerber
Nov 1, 1984·The Biochemical Journal·B SmedsrødT C Laurent
Mar 1, 1983·Experimental Cell Research·S ErikssonB Smedsrød
Jan 1, 1995·Journal of Hepatology·J GuéchotR Poupon
Apr 1, 1994·Alcoholism, Clinical and Experimental Research·M TsutsumiA Takada
Nov 1, 1993·Gastroenterology·J AisenbergL Mayer
Jan 1, 1993·Alcohol·M D Schechter, S M Meehan
Citations
Dec 4, 2003·The International Journal of Biochemistry & Cell Biology·Joseph GeorgeShujiro Takase
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sylvie NaveauThierry Poynard
Oct 10, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Roberto CatanzaroFrancesco Marotta
Feb 3, 2004·Journal of Lipid Research·Junko AdachiYasuhiro Ueno
Mar 4, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paramananda SaikiaLaura E Nagy
Sep 1, 1999·European Journal of Clinical Investigation·T OgataS Aoyagi
Sep 14, 2001·Journal of Gastroenterology and Hepatology·M TsutsumiS Takase
Jul 5, 2018·Alimentary Pharmacology & Therapeutics·N PlevrisP C Hayes
Oct 2, 1998·Alcoholism, Clinical and Experimental Research·D B HillC J McClain
Feb 25, 2010·The American Journal of Gastroenterology·David NunesDeborah Cotton
Jun 1, 2005·European Journal of Epidemiology·Norihiko KuboJun Hayashi
Nov 13, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jennifer E RowleyMichele T Pritchard