PMID: 6167284Jul 1, 1981Paper

Characteristics of skeletal muscle growth and protein turnover in a fast-growing rat strain

The British Journal of Nutrition
P C Bates, D J Millward

Abstract

1. Protein turnover and muscle composition has been studied in rat skeletal muscle throughout development in a relatively-fast-growing rat strain. 2. Muscle growth involved an increase in the total DNA and in the DNA-unit size as indicated by proteins: DNA. As a result of the latter increase together with no change in RNA: DNA, the RNA concentration fell throughout development. 3. Rates of protein synthesis measured in vivo by the continuous intravenous infusion method fell throughout development from 15.6%/d at 25 d to 4.46%/d at 320 d, and these changes reflected mainly the fall in RNA concentration, since there was no marked change in the rate of protein synthesis per unit RNA. 4. The rate of protein degradation, measured as the difference between rates of protein synthesis and growth, fell from 9.82%/d at 25 d to 4.46%/d at 320 d. 5. When these changes in protein turnover throughout development are compared with measurements made previously in a slow-growing strain it would appear that the faster growth was achieved as a result of increased efficiency of protein synthesis (defined as net synthesis: over-all synthesis) and this occurred mainly because of lower rates of protein degradation.

References

Jan 1, 1978·Biochemical Society Transactions·D J Millward
Jan 1, 1978·The International Journal of Biochemistry·R I Brinkworth, C J Masters
Nov 15, 1978·The Biochemical Journal·K MaruyamaR W Swick
Dec 1, 1976·The Proceedings of the Nutrition Society·D J Millward, P J Garlick
Nov 1, 1976·The British Journal of Nutrition·B G Vernon, P J Buttery
Aug 1, 1975·The Biochemical Journal·D J MillwardJ C Waterlow
Jun 1, 1980·Biochemical Society Transactions·J G Brown, D J Millward
Jan 1, 1981·Reproduction, Nutrition, Development·D J MillwardS Rosochacki

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Citations

Mar 1, 1987·The British Journal of Nutrition·T MuramatsuI Tasaki
Mar 1, 1990·British Poultry Science·T MuramatsuJ Okumura
Feb 1, 1994·Biological Reviews of the Cambridge Philosophical Society·W Wieser
Jan 1, 2011·Journal of Nutritional Science and Vitaminology·Aiko IshidaMasaya Katsumata
Mar 1, 1982·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J C Waterlow

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