Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin

Skin Pharmacology and Applied Skin Physiology
K ChibaM Onoue

Abstract

We have studied the effect of squalene monohydroperoxides (Sq-OOH), initial products of UV-peroxidated squalene, on the skin of hairless mice. Repeated topical application of 10 mM Sq-OOH to hairless mice for 15 weeks induced definite skin wrinkling. When image analysis was used to compare wrinkle formation induced by ultraviolet B (UVB) irradiation and Sq-OOH treatment, the degree of wrinkling in exposed skin was seen to be similar. However, the characteristics of wrinkles induced by either method differed markedly with regard to direction and distribution. Biochemical analysis revealed a significant decrease in collagen content per unit area and mass in Sq-OOH-treated skin, whereas no changes per unit area and decrease in collagen per unit mass were observed in UVB-irradiated skin. As for glycosaminoglycan (GAG) content per unit area, significant increases were observed in both Sq-OOH-treated skin and UVB-irradiated skin. These changes were not induced by organic hydroperoxides such as TERT-butylhydroperoxide or cumene hydroperoxide treatment. Histological observation revealed epidermal hyperplasia and dermal alterations such as collagen degradation and GAG increases in Sq-OOH-treated skin. Histological changes induced by Sq-...Continue Reading

Citations

Oct 29, 2010·Mediators of Inflammation·Chiara De Luca, Giuseppe Valacchi
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Feb 14, 2017·Journal of Oleo Science·Naoki ShimizuKiyotaka Nakagawa
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Aug 28, 2019·Annals of the New York Academy of Sciences·Naoki ShimizuKiyotaka Nakagawa
Jun 2, 2021·Annals of the New York Academy of Sciences·Ayano IshikawaKiyotaka Nakagawa
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irene Dini, Sonia Laneri

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