PMID: 9537024Jan 1, 1980Paper

Characteristics of suppressor cell activity appearing in cocultures of two individuals with immunodeficiency with thymoma

Scandinavian Journal of Immunology
S D Litwin

Abstract

Suppressor cell activity in two individuals (S1 and S2) with immunodeficiency with thymoma (ID-THY) was studied in peripheral blood mononuclear cells in pokeweed mitogen-stimulated single culture and cocultures. Secreted Ig was measured by radioincorporation and immunoprecipitation after 5-7 days. Control cocultures of normal/normal cells showed, in most cases, a percentage observed to expected ratio (% O/E) of cpm Ig near 100%. However, augmentation (% of O/E > 150) was often encountered, whereas suppression (% O/E < 50) was found only once in forty-two cocultures. In ID-THY/normal cell cocultures the degree of suppression by ID-THY cells varied widely when the same or different cocultivants were retested. This finding could be explained in part by an inverse correlation between the amount of secreted Ig produced by normal cells in single culture and the degree of suppression of the same normal by ID-THY cells in cocultures. A panel of normal cells were all suppressed when a range of S1 or S2/normal cell ratios were tested, weighing against genetic differences in suppressibility in the above system. ID-THY cells failed to block Ig secretion of human lymphoblastoid line cells, suggesting that the mechanism of suppression was re...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Investigation·T H HütterothJ German
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S A SchwartzY S Choi
Jun 1, 1977·The Journal of Clinical Investigation·S A SchwartzR A Good
Jul 1, 1976·The Journal of Clinical Investigation·F P SiegalR A Good
Jul 1, 1973·Clinical Immunology and Immunopathology·Z BentwichH G Kunkel
Jan 1, 1974·Contemporary Topics in Immunobiology·R K Gershon
Dec 1, 1971·European Journal of Immunology·F P SiegalH G Kunkel

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Citations

Dec 25, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leman YelSudhir Gupta
Feb 13, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Theodoros Kelesidis, Otto Yang
Feb 14, 2003·Mayo Clinic Proceedings·Brett L CucchiaraDavid King

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