Dec 1, 1970

Characteristics of the amino acid transport system in the mucosal border of rabbit ileum

The Journal of General Physiology
J J Hajjar, P F Curran


The specificity of the neutral amino acid transport system in the brush border was examined by studying the ability of amino acid analogues to inhibit the unidirectional influx of phenylalanine from mucosal solution into the cells. Effects were evaluated in terms of the affinity of various substrates for the amino acid site in the transport system. The affinity of amino acids for the site was proportional to the number of carbon atoms in the side chain. Electron-withdrawing substituents in the ring of phenylalanine increased affinity and electron-releasing groups decreased affinity. Removal of the alpha-amino group from phenylalanine decreased affinity by a factor of approximately 50 and removal of the carboxyl group decreased affinity 12-fold. Effects on affinity of variations in the side chain of the amino acid can be comparable in magnitude to that of the carboxyl group. The effect of sodium ion on the transport system appears to be similar for all compounds tested.

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Mentioned in this Paper

Amino Acids, I.V. solution additive
Brush border antigen
Structure of Intestinal Gland
Sodium Cation
Entire Ileum
Neutral Amino Acid Transport
Brush Border

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