Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio)

Developmental and Comparative Immunology
Zhiming XiangJianguo He

Abstract

The interferon regulatory factor (IRF) family plays critical roles in a host's virus infection responses. In this study, two IRF family members, zfIRF5 and zfIRF7, are identified in zebrafish. The zfIRF5 protein encodes 297 amino acids without the carboxyl IRF3 domain. We suggest that zfIRF5 is a new kind of splicing variant, following the nine other kinds of IRF5 splicing variants found in mammals. The zfIRF7 protein is identified as a member of the IRF7 family, compared to the human IRF7 protein, the amino acid sequence of zfIRF7 only with 29% identity and devoid a virus activated domain (VAD). There zfIRF5/7 proteins are expressed in all 11 selective zebrafish tissues within 6-120h of embryonic development. Laser confocal microscopy shows that the full length the proteins are separately located in the cytoplasm. Mutation experiments show that the nuclear localization signals (NLS) of zfIRF7 and zfIRF-5 are at the N-terminal and C-terminals, respectively. In the assays, zfIRF7 expression increases during infectious spleen and kidney necrosis virus (ISKNV) infection and by poly(I:C) and LPS injections, both of which activate the transcriptional activity of L8G5-luc plasmids. The over-expression of zfIRF5/7 activates the interf...Continue Reading

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Citations

Jun 23, 2012·Developmental and Comparative Immunology·Yi-Bing Zhang, Jian-Fang Gui
Apr 30, 2011·Developmental and Comparative Immunology·Zhiming XiangJianguo He
May 29, 2014·Trends in Microbiology·Jean-Pierre LevraudPierre Boudinot
Dec 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Long-Feng LuYong-An Zhang
Nov 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iliana SerifiThomais Papamarcaki
Aug 16, 2019·Journal of Virology·Long-Feng LuShun Li

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