Characteristics of the NANC post-stimulus ('rebound') contraction of the urinary bladder neck muscle in sheep

British Journal of Pharmacology
K D ThornburyJ Peake

Abstract

1. Strips of muscle from sheep bladder neck were set up for tension recording and subjected to electrical field stimulation (EFS) to stimulate their intramural nerves. 2. In the presence of atropine (1 microM) and guanethidine (1 microM), the response to 1 Hz EFS was biphasic, characterized by a relaxation during the stimulus period, followed by a post-stimulus contraction. A similar biphasic response was also seen following bolus application of nitric oxide (NO). 3. In the absence of atropine and guanethidine, the relaxations were masked by contractions during stimulation; however, the post-stimulus contraction were unaffected. L-NAME (100 microM) blocked the post-stimulus contractions and L-arginine (1 mM) restored them, suggesting that they were NO-mediated. 4. M&B 22948, a phosphodiesterase inhibitor, prolonged the relaxations and abolished the post-stimulus contractions. This suggests that rapid removal of cyclic GMP is required for post-stimulus contraction to occur. 5. When the number of pulses in the stimulus train was kept constant, the size of the post-stimulus contraction increased as the duration of the preceding period of stimulation increased. Maximal post-stimulus contractions were obtained following stimulation ...Continue Reading

References

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Citations

Mar 1, 1997·British Journal of Pharmacology·R A Lefebvre, L Barthó
Jun 1, 1997·British Journal of Pharmacology·A A IzzoF Capasso
Oct 27, 2001·Journal of Autonomic Pharmacology·P TucciC Severini
Aug 28, 2002·The Journal of Pharmacy and Pharmacology·Paolo TucciPaola Bolle
Aug 28, 2003·Diabetes·Selim CellekSalvador Moncada
Sep 18, 2002·Japanese Journal of Pharmacology·Junho LaIlsuk Yang
Feb 3, 2007·Neurourology and Urodynamics·Medardo HernándezLuis M Orensanz
Apr 22, 2006·BJU International·Viktoria WerkströmPetter Hedlund

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