PMID: 37946Jul 1, 1979

Characteristics of the reactions to N-alloantigens of lymphoid cells from hydrocortisone-stimulated and adrenalectomized mice

Biulleten' eksperimental'noĭ biologii i meditsiny
D N Maianskiĭ, A N Meilikhova


The capacity of the spleen, bone marrow and thymus cells from CBA mice (intact, adrenalectomized, and those treated with single or repeated hydrocortisone injections) to induce the lymph node type of "graft-versus-host" reaction (GVHR) in (CBA X C57BL) F1 hybrid recipients was evaluated. Two days after 2.5 mg hydrocortisone injection the capacity of the spleen and bone marrow cells to induce GVHR increased while that of the thymus cells remained unchanged. Seven and particularly 15 days after hydrocortisone injection the spleen cells became less active. Two days following repeated daily hormone injections in a dose of 0.25 mg within 18 days the thymocyte activity in GVHR increased, while that of the spleen and bone marrow cells did not change.

Related Concepts

Mice, Inbred CBA
Lymphoid Cells
Graft Vs Host Reaction
Lymph Nodes
Antigen-Antibody Reactions
Adrenal Glands
Mice, Inbred C57BL
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer

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