PMID: 15218046Jun 26, 2004Paper

Characteristics of the sarcoplasmic reticulum Ca2+-dependent ATPase from masticatory muscles

Journal of Dental Research
G A SánchezG L Alonso

Abstract

We compared the sarcoplasmic reticulum (SR) Ca-ATPase from masseter (M) and medial pterygoid (MP) muscles with that from fast muscles (FM) to examine whether its calcium transport capability and enzymatic activity are different. SR vesicles from FM, M, and MP muscles were obtained according to Champeil et al.(1985). Assays for characterization of the enzyme properties were performed. The results showed similar optimal conditions for the Ca-ATPase activity and calcium transport in M, MP, and FM. However, the maximal values of calcium transport, Ca-ATPase activity, and K(i) for thapsigargin were significantly lower in the masticatory muscles. These findings are likely related to different Ca-ATPase isoforms. Since the local anesthetics used in dentistry inhibit Ca-ATPase and calcium transport in FM, it will be important for the effects of these drugs on the Ca-ATPase of masticatory muscles to be assessed.

References

Sep 1, 1979·Experimental Cell Research·N N Malouf, G Meissner
Sep 1, 1972·Biochimica Et Biophysica Acta·S Eletr, G Inesi
Jan 1, 1982·Membrane Biochemistry·D H Haynes, M M Werber
Apr 1, 1995·Archives of Biochemistry and Biophysics·F CaravacaF Fernandez-Belda
Nov 8, 1996·Biochimica Et Biophysica Acta·D Takara, G L Alonso
Jan 31, 1997·The Journal of Biological Chemistry·F Plenge-TellecheaF Fernandez-Belda
Jan 4, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·D TakaraG L Alonso

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Citations

Aug 21, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·G A SánchezD Takara
Nov 15, 2013·European Journal of Oral Sciences·Gabriel A SánchezDelia Takara
Sep 15, 2012·Archives of Oral Biology·Gabriel Antonio SánchezDelia Takara
Feb 19, 2010·Journal of Dental Research·G A SánchezG L Alonso

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