PMID: 6134770Jul 1, 1983

Characteristics of thymus-homing bone marrow cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
F LepaultI L Weissman

Abstract

Using a short-term in vivo assay, we studied bone marrow cells capable of homing to the thymus of lethally irradiated recipients. In the bone marrow, these cells lack the T cell markers Thy-1 and Lyt. Soon after their homing into the thymus, however, the immigrants begin to express Thy-1 and Lyt antigens, but not TL antigen. Unexpectedly, Lyt antigens appear to be expressed before Thy-1. These thymus-homing bone marrow cells seem to be already separated from the B cell lineage. Most of the homing cells are engaged in the cell cycle.

Related Concepts

Monoclonal Antibodies
Cytonal
T-Lymphocyte
Cell Motility
Neoplasm of Uncertain or Unknown Behavior of Thymus
Bone Marrow
Disease of Thymus Gland
Thymic Tissue
Cell Differentiation Process
B-Lymphocytes

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