PMID: 6134770Jul 1, 1983

Characteristics of thymus-homing bone marrow cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
F LepaultI L Weissman


Using a short-term in vivo assay, we studied bone marrow cells capable of homing to the thymus of lethally irradiated recipients. In the bone marrow, these cells lack the T cell markers Thy-1 and Lyt. Soon after their homing into the thymus, however, the immigrants begin to express Thy-1 and Lyt antigens, but not TL antigen. Unexpectedly, Lyt antigens appear to be expressed before Thy-1. These thymus-homing bone marrow cells seem to be already separated from the B cell lineage. Most of the homing cells are engaged in the cell cycle.

Related Concepts

Monoclonal Antibodies
Cell Motility
Neoplasm of Uncertain or Unknown Behavior of Thymus
Bone Marrow
Disease of Thymus Gland
Thymic Tissue
Cell Differentiation Process

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