Characteristics, Risk Factors and Predictors for Candidemia in the Pediatric Intensive Care Unit at the University Hospital Centre Zagreb in Croatia: A 9-Year Retrospective Study.

The Pediatric Infectious Disease Journal
Toni MaticSanja Plesko

Abstract

Candidemia is one of the leading causes of bloodstream infections in the pediatric intensive care unit (PICU). The aim of this study was to define characteristics and risk factors for candidemia in the PICU setting and propose a predictive model to identify the patients at risk. This was a retrospective matched case-control study in the PICU during a 9-year period. Patients with candidemia were studied and matched with control patients without candidemia. Univariate analysis was performed for potential risk factors and multivariate analysis was conducted to determine the prediction score for candidemia. Forty-two cases of candidemia were matched with 84 control patients. Candida parapsilosis was the most common (71.4%) species. Risk factors independently associated with candidemia were: the use of >2 antibiotics in a maximum period of 4 weeks before the candidemia (odds ratio [OR]: 10.59; 95% confidence interval [CI]: 2.05-54.83), a previous bacterial infection in a maximum period of 4 weeks before the candidemia (OR: 5.56; 95% CI: 1.44-21.5) and the duration of PICU stay of >10 days (OR: 4.22; 95% CI: 1.02-17.41). The proposed predictive scoring system has a sensitivity of 95.24%, specificity of 76.12%, OR 64.0, 95% CI 14.2-28...Continue Reading

References

Apr 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L MacDonaldC Chenoweth
May 23, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I LevyS K Sood
Apr 27, 2000·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J Raymond, Y Aujard
Nov 10, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A Rodríguez-Núñez
Dec 12, 2001·The Pediatric Infectious Disease Journal·L SaimanUNKNOWN National Epidemiology of Mycoses Study Group
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN NIAID Mycoses Study Group
Jun 25, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sunit C SinghiArunloke Chakrabarti
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Grietje Ch BeckBenito A Yard
Dec 29, 2004·The Journal of Hospital Infection·L A BonassoliT I E Svidzinski
Jul 16, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lucia Garcia San MiguelSantiago Moreno
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theoklis E ZaoutisChris Feudtner
Jun 7, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lucia Garcia-San MiguelSantiago Moreno
May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sunit SinghiArunalok Chakrabarti
Nov 13, 2009·Indian Journal of Pediatrics·Sunit Singhi, Akash Deep
Jun 2, 2010·Current Medical Research and Opinion·Theoklis Zaoutis
Jul 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theoklis E ZaoutisRobert Gross
Mar 5, 2011·The Pediatric Infectious Disease Journal·Ankhi Dutta, Debra L Palazzi
Nov 23, 2011·Italian Journal of Pediatrics·Ali Ertug ArslankoyluSemra Erdogan
Jan 24, 2013·The Pediatric Infectious Disease Journal·Mohan PammiJoseph M Bliss
Mar 14, 2014·Indian Journal of Pediatrics·Hasan AğınGamze Gülfidan
Oct 12, 2014·Indian Journal of Pediatrics·Karthi Nallasamy, Sunit C Singhi
Nov 29, 2014·Indian Journal of Pediatrics·Charu AgrawalBhupendra Singh Chauhan
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·Brian T FisherTheoklis E Zaoutis
Jul 13, 2017·Current Medical Research and Opinion·Rachel HarringtonDavid L Horn
Sep 21, 2017·Journal of the Pediatric Infectious Diseases Society·Zoi Dorothea PanaTheoklis Zaoutis
Jan 11, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Takeshi HatachiMuneyuki Takeuchi

❮ Previous
Next ❯

Software Mentioned

MedCalc
Biotyper

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Related Papers

The New England Journal of Medicine
C M TangD W Crook
The New England Journal of Medicine
C Girmenia, P Martino
The New England Journal of Medicine
M J DiNubile
The New England Journal of Medicine
R D Cofsky
© 2021 Meta ULC. All rights reserved