PMID: 3770992Nov 15, 1986Paper

Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI

International Journal of Cancer. Journal International Du Cancer
N K SpurrW F Bodmer

Abstract

We describe the chromosomal assignment and biochemical characterization of the genetic locus controlled by a human cell surface antigen which is defined by the monoclonal antibody (MAb) AUAI. This gene product is only expressed on epithelial cells. Therefore, human-mouse somatic cell hybrids of epithelial origin were used to assign this gene to chromosome 2. Cell surface iodination of the hybrids and parental cells followed by immunoprecipitation and polyacrylamide gel electrophoresis showed that AUAI detected a single 35-kDa protein. The MAb AUAI reacted on tissue sections with a subset of normal epithelial cells, but in tumours it showed a much wider distribution, though still only on epithelium-derived tumours.

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews· de Leij LB J Kroesen
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Pignatelli, W F Bodmer
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