Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence

Endocrinology
M S JohnsonBjörn Carlsson

Abstract

High density lipoprotein (HDL) participates in reverse cholesterol transport and in the delivery of cholesterol to steroid-producing tissues. Scavenger receptor class B type I (SR-BI) was recently shown to bind HDL and mediate internalization of its cholesterol content. We have cloned the rat homolog of this receptor, determined its chromosomal location, and examined its expression in rat tissues and in a model of follicular development, ovulation, and luteinization. The predicted protein contained two transmembrane domains, a leucine zipper motif, and a peroxisomal targeting sequence. The rat and human SR-BI genes were mapped to a region previously linked between rat and human chromosomes 12. SR-BI gene expression was detected in several rat tissues, with high levels in ovarian tissue, liver, and adrenal cortex, as determined by ribonuclease protection assay and in situ hybridization. A significant increase in SR-BI gene expression was detected in the late phase of corpus luteum formation, and transcripts were abundant in corpus luteum and in thecal cells at all stages of follicular development. In conclusion, the rat SR-BI complementary DNA predicted a protein with several conserved motifs, including a putative leucine zipper...Continue Reading

References

Jan 1, 1991·The Journal of Clinical Investigation·D I GoldbergR C Pittman
Aug 1, 1990·The Journal of Clinical Investigation·A R Tall
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ Gray
Jul 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·G LevanM C Yoshida
Jul 7, 1995·The Journal of Biological Chemistry·Z WuT L Ciardelli
Jul 21, 1995·The Journal of Biological Chemistry·V FrèreS Fermandjian
Mar 31, 1995·The Journal of Biological Chemistry·M FransenP P Van Veldhoven
May 1, 1995·Journal of Virology·H B BernsteinE Hunter
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S JäckleE Windler
Mar 1, 1996·Human Reproduction Update·H BilligA J Hsueh
May 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K HelouG Levan

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Citations

May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Krieger
Aug 27, 2005·BMC Cardiovascular Disorders·Per-Arne SvenssonBjörn Carlsson
Apr 21, 2006·Biochimica Et Biophysica Acta·Daisy SahooMargery A Connelly
Dec 10, 2002·Biochemical and Biophysical Research Communications·Lene MalerødTrond Berg
Oct 3, 2003·Biochemical and Biophysical Research Communications·Barbara PlayDominique Jourdheuil-Rahmani
Dec 4, 2003·Biochemical and Biophysical Research Communications·Magnus S C JohnsonBjörn Carlsson
Jul 9, 2002·Journal of Gastroenterology and Hepatology·Magnus S C JohnsonBjörn Carlsson
Jun 23, 2001·Biology of Reproduction·C P LeoA J Hsueh
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·L RoshaniK Klinga-Levan
Sep 11, 1999·Current Opinion in Lipidology·D L WilliamsG H Rothblat
Aug 18, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Andrea Frasoldati, Roberto Valcavi
Mar 21, 2007·Journal of Lipid Research·Saj ParathathMargery A Connelly

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