Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells

Gene
S AvrahamH Avraham

Abstract

Hematopoietic stem cells (HSCs) support blood cells throughout life by utilizing their self-renewing and multilineage differentiating capabilities. Hematopoietic growth factors mediate their effects on stem cells by the tyrosine phosphorylation of proteins. Regulation of tyrosine phosphorylation is partially mediated by protein tyrosine phosphatases (PTPases). A possible mechanism by which hematopoietic stem cells maintain their self-renewing capacity and undifferentiated state is by controlling the balanced and opposing actions of protein tyrosine kinases (PTKs), receptors for growth factors, and PTPases. We have characterized the expression of PTPases in 5-fluorouracil (5-FU)-treated murine bone marrow cells, which represent a very primitive population of progenitors enriched for reconstituting stem cells, by using a consensus polymerase chain reaction (PCR) method. Several PTPases were expressed abundantly in the 5-FU-treated bone marrow stem cells. A novel PTP, termed protein tyrosine phosphatase receptor omicron (PTPRO), which is related to the homotypically adhering kappa, mu and PCP-2 receptor-type tyrosine phosphatases, was identified and characterized. We have cloned the murine and full-length human PTPRO cDNAs which s...Continue Reading

References

Jan 1, 1992·Annual Review of Cell Biology·H Charbonneau, N K Tonks
Dec 1, 1992·Seminars in Cell Biology·G J Graham, I B Pragnell
Jan 1, 1991·Annual Review of Biochemistry·G M Edelman, K L Crossin
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G J Spangrude, G R Johnson
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J SapJ Schlessinger
Jan 1, 1995·Annual Review of Immunology·J N IhleO Silvennoinen
Aug 1, 1995·The Journal of Cell Biology·S M Brady-KalnayN K Tonks
Jan 1, 1993·Annual Review of Biochemistry·W J FantlL T Williams
Nov 1, 1994·Trends in Biochemical Sciences·H Sun, N K Tonks
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A OstmanN K Tonks
May 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L B RoweE H Birkenmeier
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·M Ogawa
Jan 1, 1994·Molecular and Cellular Biology·J SapJ Schlessinger
Jan 1, 1993·Annual Review of Biochemistry·K M Walton, J E Dixon
Aug 1, 1995·Seminars in Immunology·R F Paulson, A Bernstein
Jan 1, 1995·Annual Review of Cell and Developmental Biology·S J MorrisonI L Weissman

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Citations

Nov 5, 2002·Methods : a Companion to Methods in Enzymology·Marc J RuitenbergJoost Verhaagen
Nov 5, 2002·Methods : a Companion to Methods in Enzymology·Hemanth P Nair, Larry J Young
Nov 5, 2002·Methods : a Companion to Methods in Enzymology·Jean-Charles Paterna, Hansruedi Büeler
Sep 12, 2000·Journal of Hematotherapy & Stem Cell Research·H AvrahamY Taniguchi
May 1, 2009·American Journal of Physiology. Renal Physiology·Deane S CharbaVirginia J Savin
May 1, 2009·Neurosurgery·Jaimie M HendersonNicholas Boulis
Nov 13, 2010·PloS One·Line M NordstrandArne Klungland
Apr 27, 2005·Biochemical and Biophysical Research Communications·Sébastien WälchliRob Hooft van Huijsduijnen
Mar 19, 1999·Methods : a Companion to Methods in Enzymology·H Avraham, D J Price
Dec 31, 2002·Physiological Reviews·Karl G Johnson, David Van Vactor

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