Characterization and complete genome sequences of high- and low- virulence variants of tick-borne encephalitis virus

The Journal of General Virology
G WallnerF X Heinz

Abstract

The entire genomic sequences of two strains (Hypr and 263) of the flavivirus tick-borne encephalitis (TBE) virus differing in virulence from the prototypic strain Neudoerfl were determined. Strain Hypr is a human isolate of TBE virus with a high laboratory passage history which exhibits a significantly higher neuro-invasiveness in mice compared to the prototype strain. Strain 263 is a low-passage tick-isolate with a temperature-sensitive and attenuated phenotype. Except for the heterogeneous 3' non-coding regions strains Hypr and 263 share, respectively, 97.2% and 97.6% nucleotide sequence identity with strain Neudoerfl, and differ by a total of 42 and 36 amino acids from the prototypic strain. Of these, only 12 amino acids for each of the two strains represent non-conservative differences unique to an individual strain and some of these are located at positions highly conserved among flaviviruses. Based on these observations, the potential biological significance of particular sequence differences is discussed in the context of the current knowledge about molecular determinants of flavivirus virulence.

Citations

Jun 16, 2012·Wiener medizinische Wochenschrift·Gerhard DoblerMartin Pfeffer
Mar 5, 2003·Antiviral Research·T S GritsunE A Gould
Nov 14, 2000·Virus Research·V N BakhvalovaO V Morozova
Mar 12, 2003·Vaccine·Franz X Heinz
Jun 28, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Michaela Schwaiger, Pascal Cassinotti
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Regina M KoflerChristian W Mandl
Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aukse MickieneLars Lindquist
Jun 2, 2009·Vector Borne and Zoonotic Diseases·Seok-Min YunYoung Ran Ju
Feb 26, 2005·Journal of Virology·Juliet E BryantAlan D T Barrett
Jan 1, 2013·Uirusu·Ryosuke Suzuki, Eiji Konishi
Sep 1, 1999·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·C Schrader, J Süss
May 23, 2001·The Journal of General Virology·D HayasakaI Takashima
Nov 6, 2004·Virology·C Todd DavisAlan D T Barrett
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R N CharrelX de Lamballerie
Jun 6, 2007·Journal of Virological Methods·Daniel RůzekLibor Grubhoffer
Aug 27, 2005·Journal of Medical Virology·Xiuqi HanOlli Vapalahti
Jul 4, 2019·Critical Reviews in Microbiology·Aurélie VelaySamira Fafi-Kremer
Jul 22, 2017·Viral Immunology·Rania A ZayedLobna O Elmessery
Sep 29, 2019·PLoS Neglected Tropical Diseases·Martin SelingerLibor Grubhoffer
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M ChristieW M Rosenberg
Jan 1, 1997·Springer Seminars in Immunopathology·P FarciR H Purcell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.